All Phenotypes Slc12a2<K842*> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Slc12a2^K842*
Lys842Stop
MGI:5538334

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc12a2^K842/Slc12a2^K842	involves: FVB/N	MGI:5538340

Allelic Composition	Slc12a2^K842/Slc12a2^K842
Genetic Background	involves: FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc12a2^K842* mutation (0 available); any Slc12a2 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired balance ( J:201156 )

head tossing ( J:201156 )

hyperactivity ( J:201156 )

• treatment with haloperidol alleviates hyperactivity without affecting grooming behavior in mutants at a dose that does not affect the behavior of control littermates

circling ( J:201156 )

hearing/vestibular/ear

abnormal inner ear morphology ( J:201156 )

• collapse of the membranes of the vestibular compartments

collapsed Reissner membrane ( J:201156 )

abnormal crista ampullaris morphology ( J:201156 )

• cristae degeneration

utricular degeneration ( J:201156 )

vestibular saccular degeneration ( J:201156 )

deafness ( J:201156 )

• profound

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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