All Phenotypes Atoh8<tm1.1Mlkn> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Atoh8^tm1.1Mlkn
targeted mutation 1.1, Mark L Kahn
MGI:5532929

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Atoh8^tm1.1Mlkn/Atoh8^tm1.1Mlkn	involves: 129 * C57BL/6	MGI:5532932
cn2	Atoh8^tm1.1Mlkn/Atoh8^tm1.1Mlkn Gata4^tm1.1Sad/Gata4⁺ Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺	involves: 129 * C57BL/6	MGI:5532942
cx3	Atoh8^tm1.1Mlkn/Atoh8^tm1.1Mlkn Gata4^tm1Jml/Gata4⁺	involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5532940
cx4	Atoh8^tm1.1Mlkn/Atoh8^tm1.1Mlkn Zfpm2^tm1Jml/Zfpm2⁺	involves: 129 * 129X1/SvJ * C57BL/6	MGI:5532941

Allelic Composition	Atoh8^tm1.1Mlkn/Atoh8^tm1.1Mlkn
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atoh8^tm1.1Mlkn mutation (0 available); any Atoh8 mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:203454 )

N	• viable and found at the expected Mendelian ratio at P14

Allelic Composition	Atoh8^tm1.1Mlkn/Atoh8^tm1.1Mlkn Gata4^tm1.1Sad/Gata4⁺ Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atoh8^tm1.1Mlkn mutation (0 available); any Atoh8 mutation (7 available)
Gata4^tm1.1Sad mutation (1 available); any Gata4 mutation (36 available)
Nkx2-5^tm1(cre)Rjs mutation (1 available); any Nkx2-5 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:203454 )

N	• viable and present at the expected Mendelian ratio at P1

Allelic Composition	Atoh8^tm1.1Mlkn/Atoh8^tm1.1Mlkn Gata4^tm1Jml/Gata4⁺
Genetic Background	involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atoh8^tm1.1Mlkn mutation (0 available); any Atoh8 mutation (7 available)
Gata4^tm1Jml mutation (0 available); any Gata4 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality during fetal growth through weaning, incomplete penetrance ( J:203454 )

• small decrease in viability at P1 that becomes more pronounced at P14

• expected numbers are found at E17.5 indicating loss occurs between E17.5 and P1

cardiovascular system

cardiovascular system phenotype ( J:203454 )

N	• no phenotype in the heart as measured by echocardiography or histology at E17.5 • normal myocardial or contractile function

respiratory system

respiratory system phenotype ( J:203454 )

N	• despite expression in the lung mesenchyme, no gross defects in lung development are detected

Allelic Composition	Atoh8^tm1.1Mlkn/Atoh8^tm1.1Mlkn Zfpm2^tm1Jml/Zfpm2⁺
Genetic Background	involves: 129 * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atoh8^tm1.1Mlkn mutation (0 available); any Atoh8 mutation (7 available)
Zfpm2^tm1Jml mutation (0 available); any Zfpm2 mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:203454 )

N	• viable and present at the expected Mendelian ratio at P1 and P14

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