Phenotypes associated with this allele

• Allele Symbol: Kmt2b^Gena263
• Allele Name: Gena263, Harwell
• Allele ID: MGI:5532297
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kmt2b^Gena263/Kmt2b^Gena263	involves: BALB/c * C3H/HeH	MGI:5532308
ht2	Kmt2b^Gena263/Kmt2b^+	involves: BALB/c * C3H/HeH	MGI:5532301
ht3	Kmt2b^Gena263/Kmt2b^tm1Afst	involves: 129P2/OlaHsd * BALB/c * C3H/HeH	MGI:5532306

Genotype
MGI:5532308

hm1

• Allelic Composition: Kmt2b^Gena263/Kmt2b^Gena263
• Genetic Background: involves: BALB/c * C3H/HeH

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality during fetal growth through weaning, incomplete penetrance ( J:203736 )

• fewer than expected mice are present at E14.5

perinatal lethality, complete penetrance ( J:203736 )

• no mice are born

embryonic lethality, incomplete penetrance ( J:203736 )

• fewer than expected mice are present at E8.5 and E12.5

embryo

abnormal embryo turning ( J:203736 )

rostral body truncation ( J:203736 )

• anterior truncation defects as early as E105 and up to E12.5

embryonic growth retardation ( J:203736 )

cardiovascular system

abnormal heart looping ( J:203736 )

• as early as E10.5 and up to E12.5

pericardial effusion ( J:203736 )

• as early as E10.5 and up to E12.5

growth/size/body

embryonic growth retardation ( J:203736 )

abnormal head morphology ( J:203736 )

• as early as E10.5 and up to E12.5

homeostasis/metabolism

pericardial effusion ( J:203736 )

• as early as E10.5 and up to E12.5

nervous system

exencephaly ( J:203736 )

• as early as E10.5 and up to E12.5

Genotype
MGI:5532301

ht2

• Allelic Composition: Kmt2b^Gena263/Kmt2b⁺
• Genetic Background: involves: BALB/c * C3H/HeH

homeostasis/metabolism

decreased insulin secretion ( J:203736 )

• in response to glucose challenge

increased circulating glucose level ( J:79719 , J:203736 )

• in free-fed mice (J:79719)

• in fasted mice and during intraperitoneal glucose tolerance test (J:203736)

increased circulating insulin level ( J:203736 )

• in fasted mice

increased circulating cholesterol level ( J:203736 )

increased circulating triglyceride level ( J:203736 )

impaired glucose tolerance ( J:203736 )

insulin resistance ( J:203736 )

increased liver free fatty acids level ( J:203736 )

increased liver triglyceride level ( J:203736 )

adipose tissue

increased total body fat amount ( J:203736 )

• at 12, but not 8 or 18, weeks

decreased epididymal fat pad weight ( J:203736 )

growth/size/body

increased liver weight ( J:203736 )

liver/biliary system

increased liver weight ( J:203736 )

increased liver free fatty acids level ( J:203736 )

increased liver triglyceride level ( J:203736 )

abnormal hepatocyte morphology ( J:203736 )

• ballooning hepatocyte degeneration

hepatic steatosis ( J:203736 )

endocrine/exocrine glands

enlarged pancreatic islets ( J:203736 )

decreased insulin secretion ( J:203736 )

• in response to glucose challenge

Genotype
MGI:5532306

ht3

• Allelic Composition: Kmt2b^Gena263/Kmt2b^tm1Afst
• Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H/HeH

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:203736 )

• mice die between E8.5 and E12.5

embryonic lethality between somite formation and embryo turning, incomplete penetrance ( J:203736 )

• mice die between E8.5 and E12.5

nervous system

exencephaly ( J:203736 )

cardiovascular system

pericardial effusion ( J:203736 )

homeostasis/metabolism

pericardial effusion ( J:203736 )

edema ( J:203736 )

• generalized