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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Clec7atm1.1Bpip
targeted mutation 1.1, Bernard Pipy
MGI:5529120
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Clec7atm1.1Bpip/Clec7atm1.1Bpip
Lyz2tm1(cre)Ifo/Lyz2+ 		involves: 129P2/OlaHsd * C57BL/6J MGI:5529128


Genotype
MGI:5529128
cn1
Allelic
Composition		 Clec7atm1.1Bpip/Clec7atm1.1Bpip
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clec7atm1.1Bpip mutation (0 available); any Clec7a mutation (22 available)
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:203908 )
• following C. albicans challenge, peritoneal macrophage exhibit reduced release of arachidonic acid and fail to produce TNF compared with wild-type cells
• however, macrophage exhibit normal arachidonic acid release in response to PMA and lipid metabolism
impaired macrophage phagocytosis ( J:203908 )
• of non-opsonized C. albicans
• no improvement with IL13 treatment
decreased tumor necrosis factor secretion ( J:203908 )
• in response to heat-killed C. albicans or non-opsonized zymosan
• however, response to LPS is normal
increased susceptibility to fungal infection ( J:203908 )
• following C. albicans challenge, macrophage exhibit reduced release of arachidonic acid, C. albicans phagocytosis, reactive oxygen species production (whether treated with IL13 and/or mannan or not) and yeast clearance compared with control cells

hematopoietic system
abnormal macrophage physiology ( J:203908 )
• following C. albicans challenge, peritoneal macrophage exhibit reduced release of arachidonic acid and fail to produce TNF compared with wild-type cells
• however, macrophage exhibit normal arachidonic acid release in response to PMA and lipid metabolism
impaired macrophage phagocytosis ( J:203908 )
• no improvement with IL13 treatment
• of non-opsonized C. albicans

cellular
impaired macrophage phagocytosis ( J:203908 )
• of non-opsonized C. albicans
• no improvement with IL13 treatment




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory