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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mirc14tm1.2Flv
targeted mutation 1.2, Richard A Flavell
MGI:5528993
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mirc14tm1.2Flv/Mirc14tm1.2Flv involves: C57BL/6 * C57BL/6N * FVB/N * SJL MGI:5529020
cx2
 		Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Mirc14tm1.2Flv/Mirc14tm1.2Flv 		involves: 129S1/Sv * C57BL/6 * C57BL/6N * FVB/N * SJL MGI:5529023
cx3
 		Mirc14tm1.2Flv/Mirc14tm1.2Flv
Tg(LCKprBCL2L1)12Sjk/0 		involves: C57BL/6 * C57BL/6N * FVB/N * SJL MGI:5529021
cx4
 		Mirc14tm1.2Flv/Mirc14tm1.2Flv
Tg(Cd4-TcraDN32D3)1Aben/0 		involves: C57BL/6 * C57BL/6N * FVB/N * SJL MGI:5529024
cx5
 		Mirc14tm1.2Flv/Mirc14tm1.2Flv
Mirc15tm1.2Flv/Mirc15tm1.2Flv 		involves: C57BL/6 * C57BL/6N * FVB/N * SJL MGI:5529026
cx6
 		Mirc14tm1.2Flv/Mirc14tm1.2Flv
Mirc15tm1.2Flv/Mirc15tm1.2Flv
Mirc16tm1.2Flv/Mirc16tm1.2Flv 		involves: C57BL/6 * C57BL/6N * FVB/N * SJL MGI:5529028


Genotype
MGI:5529020
hm1
Allelic
Composition		 Mirc14tm1.2Flv/Mirc14tm1.2Flv
Genetic
Background		 involves: C57BL/6 * C57BL/6N * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc14tm1.2Flv mutation (0 available); any Mirc14 mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell differentiation ( J:203157 )
• in bone marrow chimeras reconstitution experiments whether reconstituted with Mirc14-deficient or wild-type bone marrow
abnormal T cell receptor V(D)J recombination ( J:203157 )
• Jalpha gene usage is biased in favor of proximal versus distal segments
decreased double-positive T cell number ( J:203157 )
• in dexmethasone-treated mice
decreased B cell number ( J:203157 )
• in the bone marrow
decreased NK T cell number ( J:203157 )
• in the thymus, spleen and liver of mice treated with alpha- galactosylceramide CD1d1 tetramer
abnormal T cell physiology ( J:203157 )
• thymocytes exhibit reduced extracellular acidification rate indicating decreased glycolysis compared with wild-type cells
• however, thymocytes exhibit normal oxygen consumption, mitochondrial mass, and mitochondrial reactive oxygen species production
decreased thymocyte apoptosis ( J:203157 )
• in thymocytes cultured with dexamethasone
• in dexamethasone-treated mice
decreased T cell proliferation ( J:203157 )
• of double positive thymocytes

cellular
decreased thymocyte apoptosis ( J:203157 )
• in thymocytes cultured with dexamethasone
• in dexamethasone-treated mice
decreased T cell proliferation ( J:203157 )
• of double positive thymocytes

hematopoietic system
abnormal T cell differentiation ( J:203157 )
• in bone marrow chimeras reconstitution experiments whether reconstituted with Mirc14-deficient or wild-type bone marrow
abnormal T cell receptor V(D)J recombination ( J:203157 )
• Jalpha gene usage is biased in favor of proximal versus distal segments
decreased double-positive T cell number ( J:203157 )
• in dexmethasone-treated mice
decreased B cell number ( J:203157 )
• in the bone marrow
decreased NK T cell number ( J:203157 )
• in the thymus, spleen and liver of mice treated with alpha- galactosylceramide CD1d1 tetramer
abnormal T cell physiology ( J:203157 )
• thymocytes exhibit reduced extracellular acidification rate indicating decreased glycolysis compared with wild-type cells
• however, thymocytes exhibit normal oxygen consumption, mitochondrial mass, and mitochondrial reactive oxygen species production
decreased thymocyte apoptosis ( J:203157 )
• in thymocytes cultured with dexamethasone
• in dexamethasone-treated mice
decreased T cell proliferation ( J:203157 )
• of double positive thymocytes

endocrine/exocrine glands
decreased thymocyte apoptosis ( J:203157 )
• in thymocytes cultured with dexamethasone
• in dexamethasone-treated mice




Genotype
MGI:5529023
cx2
Allelic
Composition		 Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Mirc14tm1.2Flv/Mirc14tm1.2Flv
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * C57BL/6N * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm1.1Ast mutation (4 available); any Bcl2l11 mutation (32 available)
Mirc14tm1.2Flv mutation (0 available); any Mirc14 mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased NK T cell number ( J:203157 )
• in the thymus, spleen and liver of mice treated with alpha- galactosylceramide CD1d1 tetramer

hematopoietic system
decreased NK T cell number ( J:203157 )
• in the thymus, spleen and liver of mice treated with alpha- galactosylceramide CD1d1 tetramer




Genotype
MGI:5529021
cx3
Allelic
Composition		 Mirc14tm1.2Flv/Mirc14tm1.2Flv
Tg(LCKprBCL2L1)12Sjk/0
Genetic
Background		 involves: C57BL/6 * C57BL/6N * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc14tm1.2Flv mutation (0 available); any Mirc14 mutation (1 available)
Tg(LCKprBCL2L1)12Sjk mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased NK T cell number ( J:203157 )
• in the thymus, spleen and liver of mice treated with alpha- galactosylceramide CD1d1 tetramer

immune system
decreased NK T cell number ( J:203157 )
• in the thymus, spleen and liver of mice treated with alpha- galactosylceramide CD1d1 tetramer




Genotype
MGI:5529024
cx4
Allelic
Composition		 Mirc14tm1.2Flv/Mirc14tm1.2Flv
Tg(Cd4-TcraDN32D3)1Aben/0
Genetic
Background		 involves: C57BL/6 * C57BL/6N * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc14tm1.2Flv mutation (0 available); any Mirc14 mutation (1 available)
Tg(Cd4-TcraDN32D3)1Aben mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased NK T cell number ( J:203157 )
• in the thymus, spleen and liver of mice treated with alpha- galactosylceramide CD1d1 tetramer
abnormal NK T cell physiology ( J:203157 )
• decreased proliferation of developing NKT cells

hematopoietic system
decreased NK T cell number ( J:203157 )
• in the thymus, spleen and liver of mice treated with alpha- galactosylceramide CD1d1 tetramer
abnormal NK T cell physiology ( J:203157 )
• decreased proliferation of developing NKT cells




Genotype
MGI:5529026
cx5
Allelic
Composition		 Mirc14tm1.2Flv/Mirc14tm1.2Flv
Mirc15tm1.2Flv/Mirc15tm1.2Flv
Genetic
Background		 involves: C57BL/6 * C57BL/6N * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc14tm1.2Flv mutation (0 available); any Mirc14 mutation (1 available)
Mirc15tm1.2Flv mutation (0 available); any Mirc15 mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

immune system
decreased B cell number ( J:203157 )
• in the bone marrow

growth/size/body
decreased body weight ( J:203157 )

hematopoietic system
decreased B cell number ( J:203157 )
• in the bone marrow




Genotype
MGI:5529028
cx6
Allelic
Composition		 Mirc14tm1.2Flv/Mirc14tm1.2Flv
Mirc15tm1.2Flv/Mirc15tm1.2Flv
Mirc16tm1.2Flv/Mirc16tm1.2Flv
Genetic
Background		 involves: C57BL/6 * C57BL/6N * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc14tm1.2Flv mutation (0 available); any Mirc14 mutation (1 available)
Mirc15tm1.2Flv mutation (0 available); any Mirc15 mutation (2 available)
Mirc16tm1.2Flv mutation (0 available); any Mirc16 mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality, complete penetrance ( J:203157 )
• mice have yet to be obtained indicating incompatibility with life




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory