Mirc15^tm1.2Flv
Targeted Allele Detail

Summary

• Symbol: Mirc15^tm1.2Flv
• Name: microRNA cluster 15, including Mir181a-2 through Mir181b-2; targeted mutation 1.2, Richard A Flavell
• MGI ID: MGI:5528992
• Synonyms: miR-181a2/b2^-
• Gene: Mirc15 Location: Chr2:38742747-38743930 bp Genetic Position: Chr2, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:203157
• Parent Cell Line: JM8 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Mutation details: A loxP site was inserted upstream of Mir181a-2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of Mir181b-2. Flp-mediated recombination removed the neomycin resistance cassette. Cre-mediated recombination removed the microRNAs. (J:203157)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mirc15 Mutation: 2 strains or lines available

References

• Original: J:203157 Henao-Mejia J, et al., The microRNA miR-181 is a critical cellular metabolic rheostat essential for NKT cell ontogenesis and lymphocyte development and homeostasis. Immunity. 2013 May 23;38(5):984-97
• All: 3 reference(s)