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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mirc14tm1.1Flv
targeted mutation 1.1, Richard A Flavell
MGI:5528987
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Mirc14tm1.1Flv/Mirc14tm1.1Flv
Ptentm1Hwu/Ptentm1Hwu
Tg(Cd4-cre)1Cwi/0 		involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA/2 * SJL MGI:5529025
cn2
 		Mirc14tm1.1Flv/Mirc14tm1.1Flv
Tg(Cd4-cre)1Cwi/0 		involves: C57BL/6 * C57BL/6N * DBA/2 * SJL MGI:5529019


Genotype
MGI:5529025
cn1
Allelic
Composition		 Mirc14tm1.1Flv/Mirc14tm1.1Flv
Ptentm1Hwu/Ptentm1Hwu
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA/2 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc14tm1.1Flv mutation (0 available); any Mirc14 mutation (1 available)
Ptentm1Hwu mutation (17 available); any Pten mutation (86 available)
Tg(Cd4-cre)1Cwi mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:203157 )
N
• NKT cell development is rescued




Genotype
MGI:5529019
cn2
Allelic
Composition		 Mirc14tm1.1Flv/Mirc14tm1.1Flv
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: C57BL/6 * C57BL/6N * DBA/2 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc14tm1.1Flv mutation (0 available); any Mirc14 mutation (1 available)
Tg(Cd4-cre)1Cwi mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased NK T cell number ( J:203157 )
• in the thymus, spleen and liver of mice treated with alpha- galactosylceramide CD1d1 tetramer

hematopoietic system
decreased NK T cell number ( J:203157 )
• in the thymus, spleen and liver of mice treated with alpha- galactosylceramide CD1d1 tetramer




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory