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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Flot2tm1Mak
targeted mutation 1, Tak Mak
MGI:5527543
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Flot2tm1Mak/Flot2tm1Mak involves: 129P2/OlaHsd * C57BL/6 MGI:5527554
cx2
 		Flot2tm1Mak/Flot2tm1Mak
Tg(MMTV-PyVT)634Mul/0 		involves: 129P2/OlaHsd * C57BL/6 * FVB/N MGI:5527556


Genotype
MGI:5527554
hm1
Allelic
Composition		 Flot2tm1Mak/Flot2tm1Mak
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flot2tm1Mak mutation (1 available); any Flot2 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell morphology ( J:203238 )
• mouse embryonic fibroblasts fail to form functional flotilin
• however, caveolar membrane microdomains form




Genotype
MGI:5527556
cx2
Allelic
Composition		 Flot2tm1Mak/Flot2tm1Mak
Tg(MMTV-PyVT)634Mul/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flot2tm1Mak mutation (1 available); any Flot2 mutation (37 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:203238 )
• as in Tg(MMTV-PyVT)634Mul mice

neoplasm
increased mammary gland tumor incidence ( J:203238 )
• as in Tg(MMTV-PyVT)634Mul mice
decreased metastatic potential ( J:203238 )
• 10-fold fewer visible macro-metastases in the lungs compared to in Tg(MMTV-PyVT)634Mul mice
• fewer micro-metastases in the lungs compared to in Tg(MMTV-PyVT)634Mul mice

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:203238 )
• as in Tg(MMTV-PyVT)634Mul mice

integument
increased mammary gland tumor incidence ( J:203238 )
• as in Tg(MMTV-PyVT)634Mul mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory