All Phenotypes Bok<tm1.1Ast> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Bok^tm1.1Ast
targeted mutation 1.1, Andreas Strasser
MGI:5527387

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bok^tm1.1Ast/Bok^tm1.1Ast	involves: BALB/cJ * C57BL/6	MGI:5527391
cx2	Bok^tm1.1Ast/Bok^tm1.1Ast Tg(IghMyc)22Bri/0	involves: BALB/cJ * C57BL * C57BL/6 * SJL	MGI:5527392

Allelic Composition	Bok^tm1.1Ast/Bok^tm1.1Ast
Genetic Background	involves: BALB/cJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bok^tm1.1Ast mutation (0 available); any Bok mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:203179 )

N	• lymphoid organs have normal hematopoietic cell subset composition • lymphoid and myeloid cells respond normally to apoptotic stimuli

increased thymus weight ( J:203179 )

• minor in female, but not male, mice

increased spleen weight ( J:203179 )

• minor in female, but not male, mice

hematopoietic system

hematopoietic system phenotype ( J:203179 )

N	• lymphoid organs have normal hematopoietic cell subset composition

increased thymus weight ( J:203179 )

• minor in female, but not male, mice

increased spleen weight ( J:203179 )

• minor in female, but not male, mice

endocrine/exocrine glands

increased thymus weight ( J:203179 )

• minor in female, but not male, mice

growth/size/body

increased spleen weight ( J:203179 )

• minor in female, but not male, mice

Allelic Composition	Bok^tm1.1Ast/Bok^tm1.1Ast Tg(IghMyc)22Bri/0
Genetic Background	involves: BALB/cJ * C57BL * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bok^tm1.1Ast mutation (0 available); any Bok mutation (21 available)
Tg(IghMyc)22Bri mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased lymphoma incidence ( J:203179 )

• as in Tg(IghMyc)22Bri mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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