Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key mutation
(2 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(Pbsn-cre)4Prb mutation
(2 available)
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reproductive system
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• focal ventral lobe hyperplasia after 1 year of age in 50% of mice
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endocrine/exocrine glands
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• focal ventral lobe hyperplasia after 1 year of age in 50% of mice
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key mutation
(2 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(Pbsn-cre)4Prb mutation
(2 available)
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reproductive system
|
• focal ventral lobe hyperplasia after 1 year of age in 50% of mice
|
endocrine/exocrine glands
|
• focal ventral lobe hyperplasia after 1 year of age in 50% of mice
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key mutation
(2 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Ptentm2.1Ppp mutation
(0 available);
any
Pten mutation
(81 available)
Tg(Pbsn-cre)4Prb mutation
(2 available)
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mortality/aging
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• shortened survival compared with Ptentm2.1Ppp/Ptentm2.1Ppp Tg(Pbsn-cre)4Prb mice
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reproductive system
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• enlarged and hardened by 6 months
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• invasive with small irregular glandular structures composed of malignant cells with large, pleiomorphic nuclei and pale cytoplasm by 8 weeks
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• with a proliferative index only slightly higher than in Ptentm2.1Ppp/Ptentm2.1Ppp Tg(Pbsn-cre)4Prb mice
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• proliferative index only slightly higher than in Ptentm2.1Ppp/Ptentm2.1Ppp Tg(Pbsn-cre)4Prb mice
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neoplasm
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• invasive with small irregular glandular structures composed of malignant cells with large, pleiomorphic nuclei and pale cytoplasm by 8 weeks
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• with a proliferative index only slightly higher than in Ptentm2.1Ppp/Ptentm2.1Ppp Tg(Pbsn-cre)4Prb mice
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renal/urinary system
growth/size/body
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• increased abdominal girth
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endocrine/exocrine glands
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• enlarged and hardened by 6 months
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• invasive with small irregular glandular structures composed of malignant cells with large, pleiomorphic nuclei and pale cytoplasm by 8 weeks
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• with a proliferative index only slightly higher than in Ptentm2.1Ppp/Ptentm2.1Ppp Tg(Pbsn-cre)4Prb mice
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• proliferative index only slightly higher than in Ptentm2.1Ppp/Ptentm2.1Ppp Tg(Pbsn-cre)4Prb mice
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