All Phenotypes C1galt1<tm1.2Staka> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

C1galt1^tm1.2Staka
targeted mutation 1.2, Satoru Takahashi
MGI:5524267

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	C1galt1^tm1.2Staka/C1galt1^tm1.2Staka	involves: C57BL/6J * DBA/2	MGI:5524269
cn2	C1galt1^tm1.1Staka/C1galt1^tm1.2Staka Tg(Mx1-cre)1Cgn/0	involves: C57BL/6 * C57BL/6J * CBA * DBA/2	MGI:5524268

Allelic Composition	C1galt1^tm1.2Staka/C1galt1^tm1.2Staka
Genetic Background	involves: C57BL/6J * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C1galt1^tm1.2Staka mutation (0 available); any C1galt1 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:202276 )

cardiovascular system

hemorrhage ( J:202276 )

Allelic Composition	C1galt1^tm1.1Staka/C1galt1^tm1.2Staka Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: C57BL/6 * C57BL/6J * CBA * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C1galt1^tm1.1Staka mutation (0 available); any C1galt1 mutation (24 available)
C1galt1^tm1.2Staka mutation (0 available); any C1galt1 mutation (24 available)
Tg(Mx1-cre)1Cgn mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:202276 )

N	• pIpC-treated mice exhibit normal numbers of megakaryocytes in the bone marrow

abnormal megakaryocyte differentiation ( J:202276 )

• pIpC-treated mice exhibit abnormal morphology of terminally differentiated megakaryocytes

abnormal platelet morphology ( J:202276 )

• giant platelets with increased number of microtubule coils in pIpC-treated mice

thrombocytopenia ( J:202276 )

• severe in pIpC-treated mice whether or not mice are splenectomized

giant platelets ( J:202276 )

• in pIpC-treated mice

homeostasis/metabolism

increased bleeding time ( J:202276 )

• in pIpC-treated mice whether or not mice are splenectomized

cellular

abnormal megakaryocyte differentiation ( J:202276 )

• pIpC-treated mice exhibit abnormal morphology of terminally differentiated megakaryocytes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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