Phenotypes associated with this allele
Allelic Composition |
Nrg1tm4.1Cbm/Nrg1+
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Genetic Background |
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrg1tm4.1Cbm mutation
(0 available);
any
Nrg1 mutation
(53 available)
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation
(2 available);
any
H2az2 mutation
(26 available)
Nrg1tm4.1Cbm mutation
(0 available);
any
Nrg1 mutation
(53 available)
Nrg1tm4Cbm mutation
(0 available);
any
Nrg1 mutation
(53 available)
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nervous system
N |
• mice exhibit normal myelination
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• small diameter and few intrafusal fibers
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behavior/neurological
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• on an inverted grid, mice loss their grip 5 times faster than control mice
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• impaired left/right coordination with frequent hopping
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muscle
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• small diameter and few intrafusal fibers
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bace1tm1Psa mutation
(0 available);
any
Bace1 mutation
(27 available)
Nrg1tm4.1Cbm mutation
(0 available);
any
Nrg1 mutation
(53 available)
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muscle
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• large diameter and high intrafusal fiber numbers
• however, outer capsule morphology and innervation
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• more pronounced in Nrg1tm4.1Cbm homozygotes
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nervous system
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• large diameter and high intrafusal fiber numbers
• however, outer capsule morphology and innervation
|
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• more pronounced in Nrg1tm4.1Cbm homozygotes
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