All Phenotypes Nrg1<tm4Cbm> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nrg1^tm4Cbm
targeted mutation 4, Carmen Birchmeier
MGI:5524247

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Nrg1^tm4Cbm/Nrg1^tm4.1Cbm H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6J * CBA/J	MGI:5524256

Allelic Composition	Nrg1^tm4Cbm/Nrg1^tm4.1Cbm H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (25 available)
Nrg1^tm4.1Cbm mutation (0 available); any Nrg1 mutation (56 available)
Nrg1^tm4Cbm mutation (0 available); any Nrg1 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:199150 )

N	• mice exhibit normal myelination

abnormal muscle spindle morphology ( J:199150 )

• small diameter and few intrafusal fibers

decreased muscle spindle number ( J:199150 )

behavior/neurological

impaired coordination ( J:199150 )

• on an inverted grid, mice loss their grip 5 times faster than control mice

abnormal gait ( J:199150 )

• impaired left/right coordination with frequent hopping

muscle

abnormal muscle spindle morphology ( J:199150 )

• small diameter and few intrafusal fibers

decreased muscle spindle number ( J:199150 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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