All Phenotypes Hprt1<tm1.1(CAG-Smpd1)Jhkh> MGI Mouse

homeostasis/metabolism

abnormal ceramide level ( J:199833 )

• high constitutive hippocampal ceramide concentrations

abnormal physiological response to xenobiotic ( J:199833 )

• decreased neurogenesis, neuronal maturation and survival in the absence or presence of amitriptyline and fluoxetine

• however, corticosterone stressed or nonstressed mice treated with amitriptyline and fluoxetine exhibit increased in neurogenesis, neuronal maturation and survival

• however, treatment with antidepressants or fendiline normalizes behavior in corticosterone stressed or nonstressed mice

behavior/neurological

abnormal depression-related behavior ( J:199833 )

• mice exhibit depression-like behavior

• however, treatment with antidepressants or fendiline normalizes behavior in corticosterone stressed or nonstressed mice

nervous system

abnormal neuron differentiation ( J:199833 )

• decreased neurogenesis, neuronal maturation and survival in the absence or presence of amitriptyline and fluoxetine

• however, corticosterone stressed or nonstressed mice treated with amitriptyline and fluoxetine exhibit increased in neurogenesis, neuronal maturation and survival

cellular

abnormal neuron differentiation ( J:199833 )

• decreased neurogenesis, neuronal maturation and survival in the absence or presence of amitriptyline and fluoxetine

• however, corticosterone stressed or nonstressed mice treated with amitriptyline and fluoxetine exhibit increased in neurogenesis, neuronal maturation and survival

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/14/2024 MGI 6.23