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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Notch2tm3.1Rko
targeted mutation 3.1, Raphael Kopan
MGI:5523517
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Notch2tm3.1Rko/Notch2tm3.1Rko involves: C57BL/6 MGI:5523683
cx2
 		Notch1tm1Con/Notch1+
Notch2tm3.1Rko/Notch2tm3.1Grid 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5523684


Genotype
MGI:5523683
hm1
Allelic
Composition		 Notch2tm3.1Rko/Notch2tm3.1Rko
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch2tm3.1Rko mutation (0 available); any Notch2 mutation (97 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal/urinary system phenotype ( J:198632 )
N
• kidneys have functional nephrons in normal numbers; the absence of the Notch2 intracellular domain (N2ICD) does not affect nephron formation




Genotype
MGI:5523684
cx2
Allelic
Composition		 Notch1tm1Con/Notch1+
Notch2tm3.1Rko/Notch2tm3.1Grid
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch1tm1Con mutation (3 available); any Notch1 mutation (116 available)
Notch2tm3.1Grid mutation (0 available); any Notch2 mutation (97 available)
Notch2tm3.1Rko mutation (0 available); any Notch2 mutation (97 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal/urinary system phenotype ( J:198632 )
N
• kidneys have functional nephrons in normal numbers; one copy of the Notch1 intracellular domain (N1ICD) expressed from the Notch2 locus is sufficient for nephron formation




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory