All Phenotypes Porcn<tm1.1Jrt> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Porcn^tm1.1Jrt
targeted mutation 1.1, Janet Rossant
MGI:5523157

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Porcn^tm1.1Jrt/Porcn⁺	B6.Cg-Porcn^tm1.1Jrt	MGI:5523420
ht2	Porcn^tm1.1Jrt/Porcn⁺	involves: 129S6/SvEvTac * C57BL/6NCr * ICR	MGI:5523424
cn3	Porcn^tm1.1Jrt/Porcn⁺ Tg(CAG-EGFP)D4Nagy/0 Tg(Zp3-cre)3Mrt/0	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * C57BL/6NCr * FVB/N	MGI:5523431
cn4	Porcn^tm1.1Jrt/Y Tg(CAG-EGFP)D4Nagy/0 Tg(Zp3-cre)3Mrt/0	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * C57BL/6NCr * FVB/N	MGI:5523432
cn5	Porcn^tm1.1Jrt/Porcn⁺ Tg(Ttr-cre)1Hadj/0	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * CBA/J	MGI:5523430
cn6	Porcn^tm1.1Jrt/Porcn⁺ Tg(CAG-cre)1Nagy/0	involves: 129S6/SvEvTac * C57BL/6NCr * ICR	MGI:5523429
cn7	Porcn^tm1.1Jrt/Y Tg(CAG-cre)1Nagy/0	involves: 129S6/SvEvTac * C57BL/6NCr * ICR	MGI:5523428
ot8	Porcn^tm1.1Jrt/Y	B6.Cg-Porcn^tm1.1Jrt	MGI:5523417
ot9	Porcn^tm1.1Jrt/Y	involves: 129S6/SvEvTac * C57BL/6NCr * ICR	MGI:5523422

Allelic Composition	Porcn^tm1.1Jrt/Porcn⁺
Genetic Background	B6.Cg-Porcn^tm1.1Jrt

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Porcn^tm1.1Jrt mutation (1 available); any Porcn mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:198636 )

• no defects observed

• fertility normal

Allelic Composition	Porcn^tm1.1Jrt/Porcn⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NCr * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Porcn^tm1.1Jrt mutation (1 available); any Porcn mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:198636 )

• no defects observed

• fertility normal

Allelic Composition	Porcn^tm1.1Jrt/Porcn⁺ Tg(CAG-EGFP)D4Nagy/0 Tg(Zp3-cre)3Mrt/0
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * C57BL/6NCr * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Porcn^tm1.1Jrt mutation (1 available); any Porcn mutation (18 available)
Tg(CAG-EGFP)D4Nagy mutation (2 available)
Tg(Zp3-cre)3Mrt mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryo phenotype ( J:198636 )

N	• heterozygous females implant normally when the mutant allele ant the cre transgene are from the mother and the reporter is from the father

Allelic Composition	Porcn^tm1.1Jrt/Y Tg(CAG-EGFP)D4Nagy/0 Tg(Zp3-cre)3Mrt/0
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * C57BL/6NCr * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

failure to gastrulate ( J:198636 )

• hemizygous males fail to gastrulate when mutant and cre are derived from the mother and the reporter is derived from the father

Allelic Composition	Porcn^tm1.1Jrt/Porcn⁺ Tg(Ttr-cre)1Hadj/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Porcn^tm1.1Jrt mutation (1 available); any Porcn mutation (18 available)
Tg(Ttr-cre)1Hadj mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:198636 )

N	• heterozygous females present at the expected ratio at weaning

Allelic Composition	Porcn^tm1.1Jrt/Porcn⁺ Tg(CAG-cre)1Nagy/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NCr * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Porcn^tm1.1Jrt mutation (1 available); any Porcn mutation (18 available)
Tg(CAG-cre)1Nagy mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:198636 )

• embryos in which the mutant allele is derived from the mother are only recovered to E11.5

embryo

embryo phenotype ( J:198636 )

N	• chorionic plate is normal in E9.5 embryos in which the mutant allele is derived from the mother

abnormal embryo development ( J:198636 )

• embryos described above fail to thrive

abnormal allantois morphology ( J:198636 )

• a ball of allantoic tissue is found at the posterior end of the embryos described above

abnormal placenta morphology ( J:198636 )

• embryos described above fail to establish a functional placenta

abnormal umbilical cord morphology ( J:198636 )

• embryos descrbed above fail to establish a functional umbilical cord

nervous system

nervous system phenotype ( J:198636 )

N	• neural tube closure defects are very rare

Allelic Composition	Porcn^tm1.1Jrt/Y Tg(CAG-cre)1Nagy/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NCr * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Porcn^tm1.1Jrt mutation (1 available); any Porcn mutation (18 available)
Tg(CAG-cre)1Nagy mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:198636 )

• hemizygous males survive to E7.5

embryo

decreased embryo size ( J:198636 )

abnormal extraembryonic tissue morphology ( J:198636 )

absent amnion ( J:198636 )

absent chorion ( J:198636 )

growth/size/body

decreased embryo size ( J:198636 )

Allelic Composition	Porcn^tm1.1Jrt/Y
Genetic Background	B6.Cg-Porcn^tm1.1Jrt

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Porcn^tm1.1Jrt mutation (1 available); any Porcn mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:198636 )

• no defects observed

• fertility normal

Allelic Composition	Porcn^tm1.1Jrt/Y
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NCr * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Porcn^tm1.1Jrt mutation (1 available); any Porcn mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:198636 )

• no defects observed

• fertility normal

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