Analysis Tools
growth/size/body
 |
• more obvious over time
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liver/biliary system
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• pale, yellowish, hardened with rare small white nodules
• severe liver damage at 42 weeks
• however, hepatic mitochondrial cholesterol content is normal
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• more obvious over time
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• of total cholesterol at 16 weeks and more so at 42 weeks
• of free cholesterol and cholesterol ester in the liver at 42 weeks
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• 2- to 14-fold at 12 weeks
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• 8-fold at 16 weeks
• 52-fold at 42 weeks
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• foamy hepatocytes more so at 42 weeks than 16 weeks, resulting from accumulation of many small vacuoles in a hepatocyte
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• small and large vacuoles at 16 and 42 weeks
• progressive steatohepatitis
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• macrovesicular steatosis primarily located in the zone 1 and panlobular region
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• microvesicular steatosis predominantly around zones 3 and 2
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• progressive
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pale liver
(
J:199570
)
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|
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• increased hepatic oxidative stress at 42 weeks
• however, hepatic endoplasmic reticulum stress is normal
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|
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• progressive steatohepatitis
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homeostasis/metabolism
|
N |
• mice exhibit normal VLDL triglyceride and plasma lipids
• mice exhibit normal insulin sensitivity
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• reduced fatty acid oxidation in the liver
|
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• at 42 weeks
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• a few fatty acid species of diacylglycerol are decreased in the liver
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• of total cholesterol at 16 weeks and more so at 42 weeks
• of free cholesterol and cholesterol ester in the liver at 42 weeks
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• 2- to 14-fold at 12 weeks
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• decreased hepatic phospholipid at 42, but not 16, weeks
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• 8-fold at 16 weeks
• 52-fold at 42 weeks
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• reduced triglyceride hydrolase activity in the liver at 16 and 42 weeks
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immune system
|
|
• progressive steatohepatitis
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cellular
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• reduced fatty acid oxidation in the liver
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|
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• increased hepatic oxidative stress at 42 weeks
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