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Allele Symbol Allele Name Allele ID |
Tg(Thy1-Tcf4)1Mjro transgene insertion 1, Moritz J Rossner MGI:5521185 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit impaired contextual fear memory formation
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• mice exhibit impaired cued fear memory formation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• freezing performance in the novel context before conditioning and during the presentation of first auditory cue is normal, however mutants show more freezings during the presentation of tone 2 when compared with tone 1, indicating impaired trace fear conditioning
• in the remote trace memory test, during presentation of tone 1 and tone 2, mutants show less freezing and in the first interval of post-tone 1, mice also show less freezing than controls, indicating reduced remote trace fear memory formation
• in recent and remote trace memory tests, mutants show fewer freezings in a time window following auditory cue (post-tone), indicating a reduced ability to anticipate the aversive foot shock
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• mice show fewer freezings than controls when trained in the trace paradigm (exposed on consecutive day to the same context as during conditioning), indicating impaired recent contextual fear memory
(J:197081)
• prior to the cued trace memory test, mice show normal freezing behavior in a novel context, although mutants show a tendency toward lower freezing rate
(J:197081)
• however, mutants show normal remote contextual memory and normal non-associate freezing and initial acquisition
(J:197081)
• upon two foot-shocks, mice show reduced freezing in the contextual and cue memory tests, indicating impaired fear memory
(J:202664)
• however, no significant differences are seen with five tone-food sock pairings
(J:202664)
• contextual fear memory formation is slightly more altered during the dark phase at Zeitgeber times 17-19 compared with at Zeitgeber times 4-6
(J:202664)
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• for the cued trace memory test in which mice were presented with 3 tones separated temporally by periods corresponding to trace intervals, mutants show less freezings during the presentation of tone 1, 2, and 3, indicating impaired trace fear memory
(J:197081)
• upon two foot-shocks, mice show reduced freezing in the contextual and cue memory tests, indicating impaired fear memory
(J:202664)
• cued fear memory formation is slightly more altered during the dark phase at Zeitgeber times 17-19 compared with at Zeitgeber times 4-6
(J:202664)
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• on the first and second day of the reversal training on the water maze task, mice show greater escape latencies, indicating a slight impairment in cognitive flexibility
• however, mice exhibit proper visual perception and normal initial and reversal learning tasks
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• the relative time spent in the center versus the periphery is slightly but significantly less then in controls during the dark phase under dim red light at Zeitgeber times 17-19, indicating altered level of anxiety that is not observed during the light phase at Zeitgeber times 4-6
• mice, however, show similar activity, exploratory, motor and motivational behavior, and pain sensitivity as controls during light phase (Zeitgeber times 4-6)
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• prepulse inhibition is impaired indicating impaired sensorimotor gating
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• prepulse inhibition is impaired, most prominently at the 75 dB prepulse, indicating impaired sensorimotor gating
• however, startle response is normal
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| schizophrenia | DOID:5419 |
OMIM:181500 |
J:197081 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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