Phenotypes associated with this allele

• Allele Symbol: Mmp14^tm1Stjw
• Allele Name: targeted mutation 1, Stephen Weiss
• Allele ID: MGI:5520085
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Mmp14^tm1Stjw/Mmp14^tm1Stjw Twist2^tm1.1(cre)Dor/Twist2^+	involves: 129X1/SvJ * C57BL/6	MGI:5520088
cn2	Mmp14^tm1Stjw/Mmp14^tm1Stjw Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0	involves: C57BL/6 * CD-1	MGI:5520089

Genotype
MGI:5520088

cn1

• Allelic Composition: Mmp14^tm1Stjw/Mmp14^tm1Stjw; Twist2^{tm1.1(cre)Dor}/Twist2⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:198679 )

• 31 of 34 mice die by 120 to 150 days with no mice surviving beyond 10 months

skeleton

skeleton phenotype ( J:198679 )

N • mice exhibit normal osteoclast numbers

increased bone marrow adipose tissue amount ( J:198679 )

• increased bone marrow adiposity

domed cranium ( J:198679 )

decreased bone mineral density ( J:198679 )

abnormal cartilage morphology ( J:198679 )

• thickened articular cartilage

abnormal joint morphology ( J:198679 )

• thickened articular cartilage

abnormal bone ossification ( J:198679 )

delayed intramembranous bone ossification ( J:198679 )

delayed cranial suture closure ( J:198679 )

• failure of suture closure

growth/size/body

short snout ( J:198679 )

decreased body size ( J:198679 )

• by P4 to P5

decreased body weight ( J:198679 )

• by P4 to P5

postnatal growth retardation ( J:198679 )

• by P4 to P5

adipose tissue

increased bone marrow adipose tissue amount ( J:198679 )

• increased bone marrow adiposity

abnormal hypodermis fat layer morphology ( J:198679 )

• adipocytes that localized to dermal fat pads fail to generate subcutaneous fat

craniofacial

domed cranium ( J:198679 )

short snout ( J:198679 )

integument

abnormal hypodermis fat layer morphology ( J:198679 )

• adipocytes that localized to dermal fat pads fail to generate subcutaneous fat

Genotype
MGI:5520089

cn2

• Allelic Composition: Mmp14^tm1Stjw/Mmp14^tm1Stjw; Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
• Genetic Background: involves: C57BL/6 * CD-1

skeleton

skeleton phenotype ( J:198679 )

N • mice exhibit normal chondrogenesis

decreased bone mineral density ( J:198679 )

delayed intramembranous bone ossification ( J:198679 )

delayed cranial suture closure ( J:198679 )

adipose tissue

adipose tissue phenotype ( J:198679 )

N • mice exhibit normal adipogenesis