Phenotypes associated with this allele

• Allele Symbol: Trp53^tm1Thst
• Allele Name: targeted mutation 1, Thorsten Stiewe
• Allele ID: MGI:5518935
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trp53^tm1Thst/Trp53^tm1Thst	involves: 129S1/Sv * 129X1/SvJ	MGI:5518939
ht2	Trp53^tm1Thst/Trp53^+	involves: 129S1/Sv * 129X1/SvJ	MGI:5518940
ht3	Trp53^tm1Thst/Trp53^tm1.1Thst	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	MGI:5518943
cx4	Trp53^tm1Thst/Trp53^+ Tg(IghMyc)22Bri/0	involves: 129S1/Sv * 129X1/SvJ * C57BL * SJL	MGI:5518945

Genotype
MGI:5518939

hm1

• Allelic Composition: Trp53^tm1Thst/Trp53^tm1Thst
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:198482 )

• median survival is 131 days compared with over 770 days for wild-type mice

neoplasm

increased tumor incidence ( J:198482 )

• mice develop more hematological malignancy compared with Trp53^tm1.1Thst homozygotes

increased T cell derived lymphoma incidence ( J:198482 )

• in most mice

increased carcinoma incidence ( J:198482 )

• in a few mice

increased teratoma incidence ( J:198482 )

• in a few mice

immune system

decreased thymocyte apoptosis ( J:198482 )

• following gamma irradiation

• however, apoptosis response to dexamethasone is normal

cellular

abnormal cell physiology ( J:198482 )

• mouse embryonic fibroblasts infected with retroviruses expressing E1A and HRas^G12V exhibit increased tumor growth when injected subcutaneously in immunocompromised mice compared with wild-type mice

decreased cellular sensitivity to gamma-irradiation ( J:198482 )

• following whole body gamma irradiation, mice are resistant to apoptosis in the thymus, developing cerebellum and intestinal crypt compared with wild-type mice

decreased thymocyte apoptosis ( J:198482 )

• following gamma irradiation

• however, apoptosis response to dexamethasone is normal

oxidative stress ( J:198482 )

• thymocytes exhibit increased reactive oxygen species levels compared with wild-type cells

hematopoietic system

decreased thymocyte apoptosis ( J:198482 )

• following gamma irradiation

• however, apoptosis response to dexamethasone is normal

endocrine/exocrine glands

decreased thymocyte apoptosis ( J:198482 )

• following gamma irradiation

• however, apoptosis response to dexamethasone is normal

increased T cell derived lymphoma incidence ( J:198482 )

• in most mice

Genotype
MGI:5518940

ht2

• Allelic Composition: Trp53^tm1Thst/Trp53⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

mortality/aging

premature death ( J:198482 )

• median survival is 438 days compared with over 770 days for wild-type mice

neoplasm

increased tumor incidence ( J:198482 )

• malignant neoplasia in the spleen of most mice

immune system

spleen hyperplasia ( J:198482 )

• nonmalignant in a few mice

hematopoietic system

spleen hyperplasia ( J:198482 )

• nonmalignant in a few mice

growth/size/body

spleen hyperplasia ( J:198482 )

• nonmalignant in a few mice

Genotype
MGI:5518943

ht3

• Allelic Composition: Trp53^tm1Thst/Trp53^tm1.1Thst
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

mortality/aging

premature death ( J:198482 )

• median survival is 274 days compared with over 770 days for wild-type mice

neoplasm

increased tumor incidence ( J:198482 )

• malignant neoplasia in the spleen in most mice

immune system

spleen hyperplasia ( J:198482 )

• nonmalignant in a few mice

hematopoietic system

spleen hyperplasia ( J:198482 )

• nonmalignant in a few mice

growth/size/body

spleen hyperplasia ( J:198482 )

• nonmalignant in a few mice

Genotype
MGI:5518945

cx4

• Allelic Composition: Trp53^tm1Thst/Trp53⁺; Tg(IghMyc)22Bri/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL * SJL

mortality/aging

premature death ( J:198482 )

• compared with Tg(IghMyc)22Bri mice

neoplasm

increased lymphoma incidence ( J:198482 )