Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
CrxRip mutation
(0 available);
any
Crx mutation
(26 available)
|
|
|
Abnormal photoreceptor segments in CrxRip/Crx+, CrxRip/CrxRip, and Crxtm1Clc/Crxtm1Clc mice
vision/eye
|
• rapid degeneration of the photoreceptor layer between 5 and 10 weeks
|
|
• long term preservation of immature cone-like photoreceptors
|
nervous system
|
• long term preservation of immature cone-like photoreceptors
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
CrxRip mutation
(0 available);
any
Crx mutation
(26 available)
|
|
|
CrxRip/Crx+ retinal photoreceptors lack outer segments and possess very short inner segments
vision/eye
N |
• retinal outer nuclear layer thickness is preserved up to 18 months
|
|
• small with poor blood flow
|
|
• long term preservation of immature cone-like photoreceptors
• however, rod phenotype is partially rescued by transgenic expression of Nrl under the control of the Crx promoter
|
|
• very short
• however, ciliary microtubules are detected
|
|
• however, ciliary microtubules are detected
|
|
• complete absence of cone visual response at 1 month
|
|
• complete absence of rod visual response at 1 month
• however, rod phenotype is partially rescued by transgenic expression of Nrl under the control of the Crx promoter
|
cardiovascular system
|
• small with poor blood flow
|
|
• poor blood flow in retinal blood vessels
|
nervous system
|
• long term preservation of immature cone-like photoreceptors
• however, rod phenotype is partially rescued by transgenic expression of Nrl under the control of the Crx promoter
|
|
• very short
• however, ciliary microtubules are detected
|
|
• however, ciliary microtubules are detected
|