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| Caption | CrxRip/Crx+ (CrxRip/+) retinas display immature cone-like photoreceptors and long-term preservation of the outer nuclear layer. Methacrylate sections followed by H&E staining of retinas from 5-week-, 10-week-, and 9-month-old wild-type, CrxRip/Crx+, CrxRip/CrxRip, and Crxtm1Clc/Crxtm1Clc (Crx-/-) mice. The thickness of the outer nuclear layer in CrxRip/Crx+ mice is relatively well preserved at 5 weeks and remains largely unchanged at least up to 18 months. The photoreceptor layer in CrxRip/CrxRip and Crxtm1Clc/Crxtm1Clc retinas underwent rapid degeneration between 5 and 10 weeks of age. rpe, retinal pigment epithelium; os, outer segment; is, inner segment; gcl, ganglion cell layer. Scale bar: 40 um. | ||||||||
| Copyright | This image is from Roger JE, J Clin Invest 2014 Jan 2;(): and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:203337 | ||||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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