Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifi44tm1b(KOMP)Wtsi mutation
(1 available);
any
Ifi44 mutation
(39 available)
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Data Sources
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hematopoietic system
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IMPC - TCP
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immune system
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IMPC - TCP
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IMPC - TCP
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nervous system
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifi44tm1b(KOMP)Wtsi mutation
(1 available);
any
Ifi44 mutation
(39 available)
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immune system
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• mice infected intranasally with 1 x 105 PFU of respiratory syncytial virus (RSV) A2 exhibit a higher percentage of live CD8+ cells in the lungs at day 7 post-infection relative to RSV-infected wild-type controls
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• mice infected intranasally with 1 x 105 PFU of respiratory syncytial virus (RSV) A2 show a modest but significant reduction in lung CXCL10 levels at day 4 but not at day 7 post-infection relative to RSV-infected wild-type controls
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• mice infected intranasally with 1 x 105 PFU of respiratory syncytial virus (RSV) A2 show a modest but significant reduction in lung interleukin-1 beta levels at day 4 post-infection relative to RSV-infected wild-type controls
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• mice infected intranasally with 1 x 105 PFU of respiratory syncytial virus (RSV) A2 exhibit greater weight loss from 5 to 7 days post-infection (dpi), higher levels of viral RNA in lung tissue at 4 dpi but not at 7 dpi, and a higher percentage of live CD8+ cells in the lungs at 7 dpi relative to RSV-infected wild-type controls
• however, no difference is observed in total cell numbers isolated from the bronchoalveolar lavage fluid or from whole lung tissue
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hematopoietic system
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• mice infected intranasally with 1 x 105 PFU of respiratory syncytial virus (RSV) A2 exhibit a higher percentage of live CD8+ cells in the lungs at day 7 post-infection relative to RSV-infected wild-type controls
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Analysis Tools