All Phenotypes Cnih2<tm1.1Ran> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cnih2^tm1.1Ran
targeted mutation 1.1, Roger A Nicoll
MGI:5513017

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cnih2^tm1.1Ran/Cnih2^tm1.1Ran	involves: 129S6/SvEvTac * C57BL/6NTac	MGI:5513845
cn2	Cnih2^tm1.1Ran/Cnih2^tm1.1Ran	involves: 129S6/SvEvTac * C57BL/6NTac	MGI:5513846
cn3	Cnih2^tm1.1Ran/Cnih2^tm1.1Ran Neurod6^tm1(cre)Kan/Neurod6⁺	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6NTac	MGI:5513847
cn4	Cnih2^tm1.1Ran/Cnih2^tm1.1Ran Cnih3^tm1.1Ran/Cnih3^tm1.1Ran	involves: 129S6/SvEvTac * C57BL/6NTac	MGI:5513850

Allelic Composition	Cnih2^tm1.1Ran/Cnih2^tm1.1Ran
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnih2^tm1.1Ran mutation (1 available); any Cnih2 mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:197912 )

• mice are indistinguishable from wild-type mice

Allelic Composition	Cnih2^tm1.1Ran/Cnih2^tm1.1Ran
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnih2^tm1.1Ran mutation (1 available); any Cnih2 mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:197912 )

N	• NMDAR-evoked excitatory postsynaptic current amplitude and paired-pulse ratio are normal

abnormal AMPA-mediated synaptic currents ( J:197912 )

• AMPAR deactivation and desensitization in cre-treated neurons are faster than in control mice

reduced AMPA-mediated synaptic currents ( J:197912 )

• reduced AMPAR-evoked excitatory postsynaptic current amplitude with speedier decay in acute mouse slices infected with a cre-expressing adenovirus or slices transfected with cre

• reduced AMPAR somatic extrasynaptic currents in cre-treated neurons

abnormal miniature excitatory postsynaptic currents ( J:197912 )

• reduced amplitude with faster decay in cre-infected neurons

Allelic Composition	Cnih2^tm1.1Ran/Cnih2^tm1.1Ran Neurod6^tm1(cre)Kan/Neurod6⁺
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnih2^tm1.1Ran mutation (1 available); any Cnih2 mutation (11 available)
Neurod6^tm1(cre)Kan mutation (0 available); any Neurod6 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:197912 )

N	• NMDAR-evoked excitatory postsynaptic current amplitude

reduced AMPA-mediated synaptic currents ( J:197912 )

• in CA1 pyramidal neurons, dentate gyrus, and layer 2/3 pyramidal neurons in the barrel cortex

Allelic Composition	Cnih2^tm1.1Ran/Cnih2^tm1.1Ran Cnih3^tm1.1Ran/Cnih3^tm1.1Ran
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnih2^tm1.1Ran mutation (1 available); any Cnih2 mutation (11 available)
Cnih3^tm1.1Ran mutation (1 available); any Cnih3 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:197912 )

N	• cre-treated neurons exhibit normal AMPAR sensitization and cyclothiazide potentiation of kainate-induced currents

reduced AMPA-mediated synaptic currents ( J:197912 )

• reduced AMPAR-evoked excitatory postsynaptic current in cre-treated neurons to a greater extent than in activated Cnih2^tm1.1Ran neurons

reduced long-term potentiation ( J:197912 )

• in cre-treated neurons

abnormal miniature excitatory postsynaptic currents ( J:197912 )

• cre-infected neurons exhibit reduced amplitude as in activated Cnih2^tm1.1Ran neurons with faster decay than in activated Cnih2^tm1.1Ran neurons

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