Analysis Tools
mortality/aging
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• heterozygotes die shortly after birth, suggesting haploinsufficiency
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Allele Symbol Allele Name Allele ID |
Cmtm7tm2a(EUCOMM)Hmgu targeted mutation 2a, Helmholtz Zentrum Muenchen GmbH MGI:5511805 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• heterozygotes die shortly after birth, suggesting haploinsufficiency
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• greatly reduced frequency of IgM-secreting plasma cells
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• B-1a cells expressed significantly lower levels of BCR
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• B-1a cell population was dramatically reduced in the peritoneal caivty
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• impaired survival of B-1a cells
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• B-1a and B-1b cells show reduced proliferation
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• greatly reduced frequency of IgM-secreting plasma cells
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• B-1a cells expressed significantly lower levels of BCR
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• B-1a cell population was dramatically reduced in the peritoneal caivty
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• impaired survival of B-1a cells
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• B-1a and B-1b cells show reduced proliferation
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• B-1a and B-1b cells show reduced proliferation
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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