All Phenotypes Cmtm7<tm2a(EUCOMM)Hmgu> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Cmtm7^{tm2a(EUCOMM)Hmgu}/Cmtm7⁺	involves: C57BL/6 * C57BL/6N	MGI:6100916
cx2	Cmtm7^{tm2a(EUCOMM)Hmgu}/Cmtm7⁺ Rag1^tm1Fwa/Rag1^tm1Fwa	chimera involves: C57BL/6 * C57BL/6N	MGI:6100917

Allelic Composition	Cmtm7^{tm2a(EUCOMM)Hmgu}/Cmtm7⁺
Genetic Background	involves: C57BL/6 * C57BL/6N
Cell Lines	HEPD0787_6_G03

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cmtm7^{tm2a(EUCOMM)Hmgu} mutation (0 available); any Cmtm7 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:207033 )

• heterozygotes die shortly after birth, suggesting haploinsufficiency

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased plasma cell number ( J:207033 )

• greatly reduced frequency of IgM-secreting plasma cells

abnormal B-1a B cell morphology ( J:207033 )

• B-1a cells expressed significantly lower levels of BCR

decreased B-1a cell number ( J:207033 )

• B-1a cell population was dramatically reduced in the peritoneal caivty

abnormal B cell physiology ( J:207033 )

• impaired survival of B-1a cells

decreased B cell proliferation ( J:207033 )

• B-1a and B-1b cells show reduced proliferation

decreased IgG2b level ( J:207033 )

decreased IgM level ( J:207033 )

immune system

decreased plasma cell number ( J:207033 )

• greatly reduced frequency of IgM-secreting plasma cells

abnormal B-1a B cell morphology ( J:207033 )

• B-1a cells expressed significantly lower levels of BCR

decreased B-1a cell number ( J:207033 )

• B-1a cell population was dramatically reduced in the peritoneal caivty

abnormal B cell physiology ( J:207033 )

• impaired survival of B-1a cells

decreased B cell proliferation ( J:207033 )

• B-1a and B-1b cells show reduced proliferation

decreased IgG2b level ( J:207033 )

decreased IgM level ( J:207033 )

cellular

decreased B cell proliferation ( J:207033 )

• B-1a and B-1b cells show reduced proliferation

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