Phenotypes associated with this allele

• Allele Symbol: Wbp1l^{tm2a(EUCOMM)Hmgu}
• Allele Name: targeted mutation 2a, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5511627
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wbp1l^tm2a(EUCOMM)Hmgu/Wbp1l^tm2a(EUCOMM)Hmgu	involves: C57BL/6N	MGI:6458734

Genotype
MGI:6458734

hm1

• Allelic Composition: Wbp1l^{tm2a(EUCOMM)Hmgu}/Wbp1l^{tm2a(EUCOMM)Hmgu}
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:284781 )

N • mice exhibit normal numbers of T cells, monocytes, neutrophils, and the majority of progenitor populations

decreased pro-B cell number ( J:284781 )

increased dendritic cell number ( J:284781 )

• increased frequency in the spleen

increased marginal zone B cell number ( J:284781 )

• in the spleen

decreased B cell number ( J:284781 )

• reduced B cell percentage in the bone marrow

decreased B-1 B cell number ( J:284781 )

• in the peritoneal cavity

decreased pre-B cell number ( J:284781 )

abnormal pre-B cell morphology ( J:284781 )

• small increased percent in G1 phase pre-B cells

embryo

abnormal embryonic hematopoiesis ( J:284781 )

• increases in the yolk sac CD45+ KIT- cells and CD11b+ F4/80+ yolk sac macrophages

hematopoietic system

abnormal embryonic hematopoiesis ( J:284781 )

• increases in the yolk sac CD45+ KIT- cells and CD11b+ F4/80+ yolk sac macrophages

decreased pro-B cell number ( J:284781 )

increased dendritic cell number ( J:284781 )

• increased frequency in the spleen

increased marginal zone B cell number ( J:284781 )

• in the spleen

decreased B cell number ( J:284781 )

• reduced B cell percentage in the bone marrow

decreased B-1 B cell number ( J:284781 )

• in the peritoneal cavity

decreased pre-B cell number ( J:284781 )

increased hematopoietic stem cell number ( J:284781 )

• slight increased percent in Lin-SCA1+Kit+ (LSK) cells

abnormal pre-B cell morphology ( J:284781 )

• small increased percent in G1 phase pre-B cells