Phenotypes associated with this allele

• Allele Symbol: Lbh^tm1.2Kbri
• Allele Name: targeted mutation 1.2, Karoline J Briegel
• Allele ID: MGI:5511022
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lbh^tm1.2Kbri/Lbh^tm1.2Kbri	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * C57BL/6NTac	MGI:5511050

Genotype
MGI:5511050

hm1

• Allelic Composition: Lbh^tm1.2Kbri/Lbh^tm1.2Kbri
• Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Postnatal mammary gland defects in Lbh^tm1.2Kbri/Lbh^tm1.2Kbri mice

reproductive system

impaired mammary gland growth during pregnancy ( J:199325 )

♀ • reduced in size

decreased litter size ( J:199325 )

♀ • at the time of weaning from female mice that may be due to insufficient milk provision

integument

abnormal mammary gland development ( J:199325 )

♀ • delayed growth and expansion into the fat pad during puberty (6 weeks)

♀ • however, prominent terminal end buds are present at the tip of the ducts and mammary glands at 10 weeks are normal

abnormal involution of the mammary gland ( J:199325 )

♀ • reduced in size

abnormal mammary gland growth during lactation ( J:199325 )

♀ • reduced in size

♀ • attenuated differentiation of lobuli into secretory alveoli

impaired mammary gland growth during pregnancy ( J:199325 )

♀ • reduced in size

abnormal mammary gland alveolus morphology ( J:199325 )

♀ • attenuated differentiation of lobuli into secretory alveoli

mammary gland hypoplasia ( J:199325 )

♀ • during pregnancy, lactation and involution

endocrine/exocrine glands

abnormal mammary gland development ( J:199325 )

♀ • delayed growth and expansion into the fat pad during puberty (6 weeks)

♀ • however, prominent terminal end buds are present at the tip of the ducts and mammary glands at 10 weeks are normal

abnormal involution of the mammary gland ( J:199325 )

♀ • reduced in size

abnormal mammary gland growth during lactation ( J:199325 )

♀ • reduced in size

♀ • attenuated differentiation of lobuli into secretory alveoli

impaired mammary gland growth during pregnancy ( J:199325 )

♀ • reduced in size

abnormal mammary gland alveolus morphology ( J:199325 )

♀ • attenuated differentiation of lobuli into secretory alveoli

mammary gland hypoplasia ( J:199325 )

♀ • during pregnancy, lactation and involution