Phenotypes associated with this allele

• Allele Symbol: Fgl1^tm1Cuko
• Allele Name: targeted mutation 1, Chinweike Ukomadu
• Allele ID: MGI:5510996
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fgl1^tm1Cuko/Fgl1^tm1Cuko	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J	MGI:5511004

Genotype
MGI:5511004

hm1

• Allelic Composition: Fgl1^tm1Cuko/Fgl1^tm1Cuko
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Lipid accumulation in Fgl1^tm1Cuko/Fgl1^tm1Cuko livers

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:199844 )

N • mice exhibit normal insulin sensitivity, oxygen consumption, carbon dioxide production and heat production

hyperglycemia ( J:199844 )

• after partial hepatectomy

decreased circulating cholesterol level ( J:199844 )

decreased circulating HDL cholesterol level ( J:199844 )

decreased circulating free fatty acids level ( J:199844 )

decreased respiratory quotient ( J:199844 )

abnormal gluconeogenesis ( J:199844 )

• increased

impaired glucose tolerance ( J:199844 )

increased liver triglyceride level ( J:199844 )

• after partial hepatectomy

adipose tissue

increased white adipose tissue amount ( J:199844 )

abnormal brown fat cell morphology ( J:199844 )

• reduced number of nuclei

increased brown fat cell lipid droplet size ( J:199844 )

decreased white fat cell number ( J:199844 )

increased white fat cell size ( J:199844 )

liver/biliary system

increased liver triglyceride level ( J:199844 )

• after partial hepatectomy

abnormal liver weight ( J:199844 )

• liver weight to body weight ratio is smaller

• however, liver mass is normal

macrovesicular hepatic steatosis ( J:199844 )

• macrovesicular steatosis after partial hepatectomy

growth/size/body

increased body weight ( J:199844 )

• as early as 3 weeks

increased body length ( J:199844 )

behavior/neurological

behavior/neurological phenotype ( J:199844 )

N • mice exhibit normal food intake and activity