Phenotypes associated with this allele

• Allele Symbol: Sytl1^tm1Tiz
• Allele Name: targeted mutation 1, Tetsuro Izumi
• Allele ID: MGI:5509384
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sytl1^tm1Tiz/Sytl1^tm1Tiz	C3.Cg-Sytl1^tm1Tiz	MGI:5509460
cx2	Sytl1^tm1Tiz/Sytl1^tm1Tiz Sytl4^tm1Tiz/Sytl4^tm1Tiz	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NTac	MGI:5509461

Genotype
MGI:5509460

hm1

• Allelic Composition: Sytl1^tm1Tiz/Sytl1^tm1Tiz
• Genetic Background: C3.Cg-Sytl1^tm1Tiz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

decreased insulin secretion ( J:200233 )

• in response to high potassium-induced depolarization and protein kinase C activation

• in response to depolarization stimulus, undocked granule exocytosis is impaired compared to in wild-type mice

• however, glucose-stimulated insulin secretion is normal

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:200233 )

N • mice exhibit normal glucose tolerance and insulin sensitivity

decreased insulin secretion ( J:200233 )

• in response to high potassium-induced depolarization and protein kinase C activation

• in response to depolarization stimulus, undocked granule exocytosis is impaired compared to in wild-type mice

• however, glucose-stimulated insulin secretion is normal

Genotype
MGI:5509461

cx2

• Allelic Composition: Sytl1^tm1Tiz/Sytl1^tm1Tiz; Sytl4^tm1Tiz/Sytl4^tm1Tiz
• Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NTac

endocrine/exocrine glands

abnormal pancreatic beta cell morphology ( J:200233 )

• beta cells lack docked granules whose lining membrane is directly attached to the plasma membrane and have fewer granules with centers within 300 nm of the plasma membrane compared with wild-type cells

decreased insulin secretion ( J:200233 )

• glucose-stimulated

homeostasis/metabolism

decreased insulin secretion ( J:200233 )

• glucose-stimulated