Sytl4^tm1Tiz
Targeted Allele Detail

Summary

• Symbol: Sytl4^tm1Tiz
• Name: synaptotagmin-like 4; targeted mutation 1, Tetsuro Izumi
• MGI ID: MGI:3609563
• Synonyms: Grn^-
• Gene: Sytl4 Location: ChrX:132837134-132882561 bp, - strand Genetic Position: ChrX, 55.47 cM, cytoband E3
• Alliance: Sytl4^tm1Tiz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102610
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A pgk-driven neomycin resistance cassette replaced exons 3-5. Protein was not detected in immunoblots of mutant pancreatic islets. (J:102610)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sytl4 Mutation: 8 strains or lines available

References

• Original: J:102610 Gomi H, et al., Granuphilin molecularly docks insulin granules to the fusion machinery. J Cell Biol. 2005 Oct 10;171(1):99-109
• All: 6 reference(s)