Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm1(Cacna1c*)Red}
• Allele Name: targeted mutation 1, Ricardo Dolmetsch
• Allele ID: MGI:5508369
• Summary: 7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm1(Cacna1c*)Red/Gt(ROSA)26Sor^+ Foxg1^tm1(cre)Skm/Foxg1^+	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	MGI:5508374
cn2	Gt(ROSA)26Sor^tm1(Cacna1c*)Red/Gt(ROSA)26Sor^+ Tg(Ins2-cre)25Mgn/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA	MGI:8266444
cn3	Gt(ROSA)26Sor^tm1(Cacna1c*)Red/Gt(ROSA)26Sor^+ Tg(Ins1-cre/ERT)1Lphi/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1	MGI:8266442
cn4	A1cf^Tg(Myh6-cre/Esr1*)1Jmk/A1cf^+ Gt(ROSA)26Sor^tm1(Cacna1c*)Red/Gt(ROSA)26Sor^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N	MGI:8249177
cn5	Gt(ROSA)26Sor^tm1(Cacna1c*)Red/Gt(ROSA)26Sor^+ Tg(Prrx1-cre)1Cjt/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J	MGI:8270564
cn6	A1cf^Tg(Myh6-cre/Esr1*)1Jmk/A1cf^+ Gt(ROSA)26Sor^tm1(Cacna1c*)Red/Gt(ROSA)26Sor^+	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:8266445
cn7	Gt(ROSA)26Sor^tm1(Cacna1c*)Red/Gt(ROSA)26Sor^+ Tg(Pomc1-cre)16Lowl/0	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:8266446

Genotype
MGI:5508374

cn1

• Allelic Composition: Gt(ROSA)26Sor^{tm1(Cacna1c*)Red}/Gt(ROSA)26Sor⁺; Foxg1^tm1(cre)Skm/Foxg1⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuron morphology ( J:199433 )

• fewer cortical neurons expressing Satb2

• however, the number of Foxp1 and total neuron numbers are normal

Genotype
MGI:8266444

cn2

• Allelic Composition: Gt(ROSA)26Sor^{tm1(Cacna1c*)Red}/Gt(ROSA)26Sor⁺; Tg(Ins2-cre)25Mgn/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:361120 )

♂N • mice fail to elicit a differential response in a glucose tolerance test

Genotype
MGI:8266442

cn3

• Allelic Composition: Gt(ROSA)26Sor^{tm1(Cacna1c*)Red}/Gt(ROSA)26Sor⁺; Tg(Ins1-cre/ERT)1Lphi/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:361120 )

♂N • in a glucose tolerance test, tamoxifen-treated mice show no differences in basal blood glucose or after an i.p. glucose bolus compared to controls

Genotype
MGI:8249177

cn4

• Allelic Composition: A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺; Gt(ROSA)26Sor^{tm1(Cacna1c*)Red}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

cardiovascular system

prolonged QT interval ( J:372210 )

• mice show prolongation of the QT interval at 4 days after tamoxifen administration

• mice treated with dextromethorphan and low dose of quinidine show shortening of the prolonged QT interval

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Timothy syndrome		DOID:0060173	OMIM:601005	J:372210

Genotype
MGI:8270564

cn5

• Allelic Composition: Gt(ROSA)26Sor^{tm1(Cacna1c*)Red}/Gt(ROSA)26Sor⁺; Tg(Prrx1-cre)1Cjt/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

craniofacial

long mandible ( J:197612 )

• in 6 of 7 mice, the tip of the mandible extends anteriorly as far as, or beyond, the tip of the maxilla

• relatively larger mandible

growth/size/body

long mandible ( J:197612 )

• in 6 of 7 mice, the tip of the mandible extends anteriorly as far as, or beyond, the tip of the maxilla

• relatively larger mandible

skeleton

long mandible ( J:197612 )

• in 6 of 7 mice, the tip of the mandible extends anteriorly as far as, or beyond, the tip of the maxilla

• relatively larger mandible

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Timothy syndrome		DOID:0060173	OMIM:601005	J:197612

Genotype
MGI:8266445

cn6

• Allelic Composition: A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺; Gt(ROSA)26Sor^{tm1(Cacna1c*)Red}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

cardiovascular system

prolonged QT interval ( J:361120 )

♂ • tamoxifen-treated mice show an increase in the electrocardiographic rate-corrected QT interval (QTc)

Genotype
MGI:8266446

cn7

• Allelic Composition: Gt(ROSA)26Sor^{tm1(Cacna1c*)Red}/Gt(ROSA)26Sor⁺; Tg(Pomc1-cre)16Lowl/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

homeostasis/metabolism

improved glucose tolerance ( J:361120 )

♂ • in a glucose tolerance test, mice show a reduction in blood glucose excursion

♂ • however, no difference in serum glucagon or insulin levels are seen

growth/size/body

growth/size/body region phenotype ( J:361120 )

♂N • mice show no difference in body mass