Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm1(Cacna1c*)Red}
• Allele Name: targeted mutation 1, Ricardo Dolmetsch
• Allele ID: MGI:5508369
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm1(Cacna1c*)Red/Gt(ROSA)26Sor^+ Foxg1^tm1(cre)Skm/Foxg1^+	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	MGI:5508374
cn2	A1cf^Tg(Myh6-cre/Esr1*)1Jmk/A1cf^+ Gt(ROSA)26Sor^tm1(Cacna1c*)Red/Gt(ROSA)26Sor^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N	MGI:8249177

Genotype
MGI:5508374

cn1

• Allelic Composition: Gt(ROSA)26Sor^{tm1(Cacna1c*)Red}/Gt(ROSA)26Sor⁺; Foxg1^tm1(cre)Skm/Foxg1⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuron morphology ( J:199433 )

• fewer cortical neurons expressing Satb2

• however, the number of Foxp1 and total neuron numbers are normal

Genotype
MGI:8249177

cn2

• Allelic Composition: A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺; Gt(ROSA)26Sor^{tm1(Cacna1c*)Red}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

cardiovascular system

prolonged QT interval ( J:372210 )

• mice show prolongation of the QT interval at 4 days after tamoxifen administration

• mice treated with dextromethorphan and low dose of quinidine show shortening of the prolonged QT interval

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Timothy syndrome		DOID:0060173	OMIM:601005	J:372210