Tg(Ins1-cre/ERT)1Lphi
Transgene Detail
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Symbol: |
Tg(Ins1-cre/ERT)1Lphi |
Name: |
transgene insertion 1, Louis Philipson |
MGI ID: |
MGI:4410453 |
Synonyms: |
MIP-CreER, MIP-Cre/ERT, MIP-CreERT1Lphi |
Transgene: |
Tg(Ins1-cre/ERT)1Lphi Location: unknown
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Alliance: |
Tg(Ins1-cre/ERT)1Lphi page
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Transgene Type: |
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Transgenic (Inducible, Recombinase) |
Inducer: |
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tamoxifen |
Mutation: |
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Insertion
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Tg(Ins1-cre/ERT)1Lphi expression driven by
1 gene
Transgene expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Ins1 (MGI:96572) |
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Mutation details: An 8.3 kb fragment of the mouse insulin promoter (Ins1; from nucleotide -8280 to +12 relative to the transcriptional start site) drives cDNA encoding cre recombinase fused to the mutated mouse estrogen receptor ligand-binding domain. A 2.1 kb fragment of the hGH gene was added to function as a transcriptional stop signal. The 12.5 kb construct was purified and microinjected into fertilized pronuclei of CD1 mice. Line 1 was established.
(J:169727)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Ins1
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:169727 Wicksteed B, et al., Conditional gene targeting in mouse pancreatic ss-Cells: analysis of ectopic Cre transgene expression in the brain. Diabetes. 2010 Dec;59(12):3090-8 |
All: |
93 reference(s) |
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