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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ralbtm1.1Cjm
targeted mutation 1.1, Christopher J Marshall
MGI:5505278
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ralbtm1.1Cjm/Ralbtm1.1Cjm involves: C57BL/6 * C57BL/6J MGI:5505292
cn2
 		Krastm4Tyj/Kras+
Ralatm1.2Cjm/Ralatm1.2Cjm
Ralbtm1.1Cjm/Ralbtm1.2Cjm 		involves: 129S4/SvJae * C57BL/6 * C57BL/6J MGI:5505293
cn3
 		Ralatm1.2Cjm/Ralatm1.2Cjm
Ralbtm1.1Cjm/Ralbtm1.1Cjm 		involves: C57BL/6 * C57BL/6J MGI:5505287
cx4
 		Ralatm1.1Cjm/Ralatm1.1Cjm
Ralbtm1.1Cjm/Ralb+ 		involves: C57BL/6 * C57BL/6J MGI:5505289
cx5
 		Ralatm1.1Cjm/Rala+
Ralbtm1.1Cjm/Ralbtm1.1Cjm 		involves: C57BL/6 * C57BL/6J MGI:5505290
cx6
 		Ralatm1.1Cjm/Ralatm1.1Cjm
Ralbtm1.1Cjm/Ralbtm1.1Cjm 		involves: C57BL/6 * C57BL/6J MGI:5505291


Genotype
MGI:5505292
hm1
Allelic
Composition		 Ralbtm1.1Cjm/Ralbtm1.1Cjm
Genetic
Background		 involves: C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ralbtm1.1Cjm mutation (0 available); any Ralb mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:199742 )
• mice displayed no obvious abnormalities including normal DMBA-TPA-induced tumor formation




Genotype
MGI:5505293
cn2
Allelic
Composition		 Krastm4Tyj/Kras+
Ralatm1.2Cjm/Ralatm1.2Cjm
Ralbtm1.1Cjm/Ralbtm1.2Cjm
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (76 available)
Ralatm1.2Cjm mutation (2 available); any Rala mutation (26 available)
Ralbtm1.1Cjm mutation (0 available); any Ralb mutation (47 available)
Ralbtm1.2Cjm mutation (2 available); any Ralb mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased tumor growth/size ( J:199742 )
• in a model of non-small cell lung carcinoma, mice exposed to a cre-expressing adenovirus exhibit fewer tumors and smaller tumor area compared with Krastm4Tyj/Kras+ Ralatm1.2Cjm/Rala+ Ralbtm1.1Cjm/Ralbtm1.2Cjm control mice




Genotype
MGI:5505287
cn3
Allelic
Composition		 Ralatm1.2Cjm/Ralatm1.2Cjm
Ralbtm1.1Cjm/Ralbtm1.1Cjm
Genetic
Background		 involves: C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ralatm1.2Cjm mutation (2 available); any Rala mutation (26 available)
Ralbtm1.1Cjm mutation (0 available); any Ralb mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased fibroblast proliferation ( J:199742 )
• in mouse embryonic fibroblasts infected with a cre-expressing adenovirus




Genotype
MGI:5505289
cx4
Allelic
Composition		 Ralatm1.1Cjm/Ralatm1.1Cjm
Ralbtm1.1Cjm/Ralb+
Genetic
Background		 involves: C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ralatm1.1Cjm mutation (0 available); any Rala mutation (26 available)
Ralbtm1.1Cjm mutation (0 available); any Ralb mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal neural tube morphology ( J:199742 )
• severe in all mice at E10.5 to E13.5
open neural tube ( J:199742 )
• at the forebrain/midbrain boundary, hindbrain/cervical boundary and caudally

growth/size/body
embryonic growth retardation ( J:199742 )

nervous system
abnormal neural tube morphology ( J:199742 )
• severe in all mice at E10.5 to E13.5
open neural tube ( J:199742 )
• at the forebrain/midbrain boundary, hindbrain/cervical boundary and caudally




Genotype
MGI:5505290
cx5
Allelic
Composition		 Ralatm1.1Cjm/Rala+
Ralbtm1.1Cjm/Ralbtm1.1Cjm
Genetic
Background		 involves: C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ralatm1.1Cjm mutation (0 available); any Rala mutation (26 available)
Ralbtm1.1Cjm mutation (0 available); any Ralb mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
embryo phenotype ( J:199742 )
N
• normal neural tube development

growth/size/body
embryonic growth retardation ( J:199742 )
• in some mice

nervous system
nervous system phenotype ( J:199742 )
N
• normal neural tube development




Genotype
MGI:5505291
cx6
Allelic
Composition		 Ralatm1.1Cjm/Ralatm1.1Cjm
Ralbtm1.1Cjm/Ralbtm1.1Cjm
Genetic
Background		 involves: C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ralatm1.1Cjm mutation (0 available); any Rala mutation (26 available)
Ralbtm1.1Cjm mutation (0 available); any Ralb mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:199742 )
• no mice are detected between E10.5 and E13.5




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory