Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarcc2tm1.1Stoy mutation
(0 available);
any
Smarcc2 mutation
(56 available)
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normal phenotype
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• mice are viable and fertile with no apparent abnormalities
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarcc2tm1.1Stoy mutation
(0 available);
any
Smarcc2 mutation
(56 available)
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nervous system
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• in E13.5 brains electroporated with a cre-expressing plasmid, radial glial progenitors are biased to asymmetric nonneurogenic divisions and the production of intermediate progenitors instead of neurons
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cellular
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• in E13.5 brains electroporated with a cre-expressing plasmid, radial glial progenitors are biased to asymmetric nonneurogenic divisions and the production of intermediate progenitors instead of neurons
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1(cre)Krj mutation
(2 available);
any
Emx1 mutation
(34 available)
Smarcc2tm1.1Stoy mutation
(0 available);
any
Smarcc2 mutation
(56 available)
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nervous system
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• increase in indirect neurogenesis
• however, neuron migration and apoptosis are normal
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• radial glial progenitors are biased to asymmetric nonneurogenic divisions and the production of intermediate progenitors instead of neurons
• however, proliferative capacity of intermediate progenitors is normal
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• increased volume, surface area, anterior-posterior dimension and dorsoventral dimension
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• in the rostral, intermediate and caudal areas
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• twice as many nonapical pHH3+ (mitotic marker) cells in the cortex at E14.5
• increased Tbr2+ cells in the subventricular zone at E12.5 with progressive increase between E13.5 and E15.5
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cellular
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• increase in indirect neurogenesis
• however, neuron migration and apoptosis are normal
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• radial glial progenitors are biased to asymmetric nonneurogenic divisions and the production of intermediate progenitors instead of neurons
• however, proliferative capacity of intermediate progenitors is normal
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• decreased CpG methylation on Cux1 and Tie1 promoters
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nervous system
N |
• mice exhibit normal cortical surface at P8 and numbers of Tbr2+ intermediate progenitors at E14.5
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• mice exhibit increased production of Cux1+ upper layer identity neurons
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nervous system
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• decreased cortical surface at P8
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• reduced of Cux1+ upper layer identity neurons
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• decreased Tbr2+ cells in E14.5 dorsal cortex
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neurod6tm1(cre)Kan mutation
(0 available);
any
Neurod6 mutation
(17 available)
Smarcc2tm1.1Stoy mutation
(0 available);
any
Smarcc2 mutation
(56 available)
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nervous system
N |
• the number of cortical progenitors and neuronal production is normal
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