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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm1(CAG-NPM1*)Geno
targeted mutation 1, Genoway
MGI:5502770
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1(CAG-NPM1*)Geno/Gt(ROSA)26Sor+
Tg(Mx1-cre)1Cgn/0 		involves: C57BL/6 * CBA MGI:5502779
cn2
 		Gt(ROSA)26Sortm1(CAG-NPM1*)Geno/Gt(ROSA)26Sortm1(CAG-NPM1*)Geno
Tg(Mx1-cre)1Cgn/0 		involves: C57BL/6 * CBA MGI:5502780


Genotype
MGI:5502779
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1(CAG-NPM1*)Geno/Gt(ROSA)26Sor+
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CAG-NPM1*)Geno mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal megakaryocyte differentiation ( J:196690 )
• expansion of immature megakaryocytes and blocked differentiation in pIpC-treated mice
enlarged spleen ( J:196690 )
• mild in pIpC-treated mice
myeloid hyperplasia ( J:196690 )
• in the bone marrow and spleen of pIpC-treated mice
increased megakaryocyte cell number ( J:196690 )
• 2-fold in the bone marrow in pIpC-treated mice
abnormal platelet morphology ( J:196690 )
• larger in size in pIpC-treated mice compared to in control mice
thrombocytopenia ( J:196690 )
• in pIpC-treated mice

cellular
abnormal megakaryocyte differentiation ( J:196690 )
• expansion of immature megakaryocytes and blocked differentiation in pIpC-treated mice

immune system
enlarged spleen ( J:196690 )
• mild in pIpC-treated mice
myeloid hyperplasia ( J:196690 )
• in the bone marrow and spleen of pIpC-treated mice

growth/size/body
enlarged spleen ( J:196690 )
• mild in pIpC-treated mice




Genotype
MGI:5502780
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1(CAG-NPM1*)Geno/Gt(ROSA)26Sortm1(CAG-NPM1*)Geno
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CAG-NPM1*)Geno mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal megakaryocyte differentiation ( J:196690 )
• expansion of immature megakaryocytes and blocked differentiation in pIpC-treated mice

hematopoietic system
abnormal megakaryocyte differentiation ( J:196690 )
• expansion of immature megakaryocytes and blocked differentiation in pIpC-treated mice
enlarged spleen ( J:196690 )
• mild in pIpC-treated mice
increased megakaryocyte cell number ( J:196690 )
• 4-fold in the bone marrow in pIpC-treated mice
abnormal platelet morphology ( J:196690 )
• larger in size in pIpC-treated mice compared to in control mice
thrombocytopenia ( J:196690 )
• in pIpC-treated mice

immune system
enlarged spleen ( J:196690 )
• mild in pIpC-treated mice

growth/size/body
enlarged spleen ( J:196690 )
• mild in pIpC-treated mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory