About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm1(CAG-NPM1*)Geno
targeted mutation 1, Genoway
MGI:5502770
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1(CAG-NPM1*)Geno/Gt(ROSA)26Sor+
Tg(Mx1-cre)1Cgn/0 		involves: C57BL/6 * CBA MGI:5502779
cn2
 		Gt(ROSA)26Sortm1(CAG-NPM1*)Geno/Gt(ROSA)26Sortm1(CAG-NPM1*)Geno
Tg(Mx1-cre)1Cgn/0 		involves: C57BL/6 * CBA MGI:5502780


Genotype
MGI:5502779
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1(CAG-NPM1*)Geno/Gt(ROSA)26Sor+
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CAG-NPM1*)Geno mutation (1 available); any Gt(ROSA)26Sor mutation (1046 available)
Tg(Mx1-cre)1Cgn mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal megakaryocyte differentiation ( J:196690 )
• expansion of immature megakaryocytes and blocked differentiation in pIpC-treated mice
enlarged spleen ( J:196690 )
• mild in pIpC-treated mice
myeloid hyperplasia ( J:196690 )
• in the bone marrow and spleen of pIpC-treated mice
increased megakaryocyte cell number ( J:196690 )
• 2-fold in the bone marrow in pIpC-treated mice
abnormal platelet morphology ( J:196690 )
• larger in size in pIpC-treated mice compared to in control mice
thrombocytopenia ( J:196690 )
• in pIpC-treated mice

cellular
abnormal megakaryocyte differentiation ( J:196690 )
• expansion of immature megakaryocytes and blocked differentiation in pIpC-treated mice

immune system
enlarged spleen ( J:196690 )
• mild in pIpC-treated mice
myeloid hyperplasia ( J:196690 )
• in the bone marrow and spleen of pIpC-treated mice

growth/size/body
enlarged spleen ( J:196690 )
• mild in pIpC-treated mice




Genotype
MGI:5502780
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1(CAG-NPM1*)Geno/Gt(ROSA)26Sortm1(CAG-NPM1*)Geno
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CAG-NPM1*)Geno mutation (1 available); any Gt(ROSA)26Sor mutation (1046 available)
Tg(Mx1-cre)1Cgn mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal megakaryocyte differentiation ( J:196690 )
• expansion of immature megakaryocytes and blocked differentiation in pIpC-treated mice

hematopoietic system
abnormal megakaryocyte differentiation ( J:196690 )
• expansion of immature megakaryocytes and blocked differentiation in pIpC-treated mice
enlarged spleen ( J:196690 )
• mild in pIpC-treated mice
increased megakaryocyte cell number ( J:196690 )
• 4-fold in the bone marrow in pIpC-treated mice
abnormal platelet morphology ( J:196690 )
• larger in size in pIpC-treated mice compared to in control mice
thrombocytopenia ( J:196690 )
• in pIpC-treated mice

immune system
enlarged spleen ( J:196690 )
• mild in pIpC-treated mice

growth/size/body
enlarged spleen ( J:196690 )
• mild in pIpC-treated mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory