immune system
N |
• tamoxifen-treated mice exhibit normal invariant NKT cell numbers, phenotype and in vivo responsiveness to lipid antigens
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• in vitro TCR-induced invariant NKT (iNKT) cell cytotoxicity from tamoxifen-treated mice is impaired compared to in control cells
• iNKT cells from tamoxifen-treated mice exhibit impaired control of tumor growth in vivo compared with control cells
• in response to EL4 targets, iNKT cells from tamoxifen-treated mcie form fewer conjugates and produce reduced levels of cytokines (IFN-gamma and IL4) compared with control cells
• however, iNKT cells exhibit normal trafficking to the tumor site
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• from iNKT cells from tamoxifen-treated mice in response to EL4 targets
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• from iNKT cells from tamoxifen-treated mice in response to EL4 targets
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homeostasis/metabolism
• from iNKT cells from tamoxifen-treated mice in response to EL4 targets
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hematopoietic system
• in vitro TCR-induced invariant NKT (iNKT) cell cytotoxicity from tamoxifen-treated mice is impaired compared to in control cells
• iNKT cells from tamoxifen-treated mice exhibit impaired control of tumor growth in vivo compared with control cells
• in response to EL4 targets, iNKT cells from tamoxifen-treated mcie form fewer conjugates and produce reduced levels of cytokines (IFN-gamma and IL4) compared with control cells
• however, iNKT cells exhibit normal trafficking to the tumor site
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