All Phenotypes Rheb<tm1.1Otsu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rheb^tm1.1Otsu
targeted mutation 1.1, Kinya Otsu
MGI:5502740

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rheb^tm1.1Otsu/Rheb^tm1.1Otsu	involves: 129 * C57BL/6J	MGI:5502746
cn2	Rheb^tm1.1Otsu/Rheb^tm1.1Otsu Tg(Myh6-cre)2182Mds/0	involves: 129 * C57BL/6J * FVB/N	MGI:5502747
cn3	Eif4ebp1^tm1Nso/Eif4ebp1^tm1Nso Rheb^tm1.1Otsu/Rheb^tm1.1Otsu Tg(Myh6-cre)2182Mds/0	involves: 129 * C57BL/6J * FVB/N	MGI:5502748
cn4	Atg5^tm1Myok/Atg5^tm1Myok Rheb^tm1.1Otsu/Rheb^tm1.1Otsu Tg(Myh6-cre)2182Mds/0	involves: 129S/SvEv * C57BL/6J * FVB/N	MGI:5502749

Allelic Composition	Rheb^tm1.1Otsu/Rheb^tm1.1Otsu
Genetic Background	involves: 129 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rheb^tm1.1Otsu mutation (0 available); any Rheb mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:197831 )

• mice appeared normal

Allelic Composition	Rheb^tm1.1Otsu/Rheb^tm1.1Otsu Tg(Myh6-cre)2182Mds/0
Genetic Background	involves: 129 * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rheb^tm1.1Otsu mutation (0 available); any Rheb mutation (26 available)
Tg(Myh6-cre)2182Mds mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Sarcomere maturation is attenuated in Rheb^tm1.1Otsu/Rheb^tm1.1Otsu Tg(Myh6-cre)2182Mds/0 hearts

mortality/aging

postnatal lethality, complete penetrance ( J:197831 )

• mice die between P8 and P10

cardiovascular system

decreased myocardial fiber size ( J:197831 )

• at P8

thin interventricular septum ( J:197831 )

decreased heart weight ( J:197831 )

• at P8

abnormal heart left ventricle morphology ( J:197831 )

• reduced diastolic left ventricle posterior wall thickness

• larger end-diastolic and systolic dimensions

decreased cardiac muscle contractility ( J:197831 )

• reduced fractional shortening at P8

• however, cardiac function is normal until P5

cardiomyopathy ( J:197831 )

• without the involvement of autophagy

muscle

decreased myocardial fiber size ( J:197831 )

• at P8

decreased cardiac muscle contractility ( J:197831 )

• reduced fractional shortening at P8

• however, cardiac function is normal until P5

cardiomyopathy ( J:197831 )

• without the involvement of autophagy

abnormal sarcomere morphology ( J:197831 )

• sarcomere maturation is attenuated

Allelic Composition	Eif4ebp1^tm1Nso/Eif4ebp1^tm1Nso Rheb^tm1.1Otsu/Rheb^tm1.1Otsu Tg(Myh6-cre)2182Mds/0
Genetic Background	involves: 129 * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif4ebp1^tm1Nso mutation (2 available); any Eif4ebp1 mutation (33 available)
Rheb^tm1.1Otsu mutation (0 available); any Rheb mutation (26 available)
Tg(Myh6-cre)2182Mds mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:197831 )

• improved survival compared to in Rheb^tm1.1Otsu/Rheb^tm1.1Otsu Tg(Myh6-cre)2182Mds mice

cardiovascular system

cardiovascular system phenotype ( J:197831 )

N	• mice exhibit improved cardiac function, hypertrophic growth and sarcomere maturation compared with Rheb^tm1.1Otsu/Rheb^tm1.1Otsu Tg(Myh6-cre)2182Mds mice

Allelic Composition	Atg5^tm1Myok/Atg5^tm1Myok Rheb^tm1.1Otsu/Rheb^tm1.1Otsu Tg(Myh6-cre)2182Mds/0
Genetic Background	involves: 129S/SvEv * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg5^tm1Myok mutation (3 available); any Atg5 mutation (27 available)
Rheb^tm1.1Otsu mutation (0 available); any Rheb mutation (26 available)
Tg(Myh6-cre)2182Mds mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:197831 )

• mice die around P10

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