All Phenotypes Plin4<tm1Vlcg> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plin4^tm1Vlcg/Plin4^tm1Vlcg	B6.Cg-Plin4^tm1Vlcg	MGI:5502552
cx2	Lep^ob/Lep^ob Plin4^tm1Vlcg/Plin4^tm1Vlcg	involves: C57BL/6J	MGI:5502553

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:195987 )

N	• heart function is normal

decreased cardiac muscle triglyceride level ( J:195987 )

• in the left ventricle of fasted mice

• mice are protected from cardiac steatosis induced by prolonged fasting or feeding of a high-fat diet compared with wild-type mice

• however, mice exhibit normal levels in brown adipose tissue, soleus muscle and liver

muscle

decreased cardiac muscle triglyceride level ( J:195987 )

• in the left ventricle of fasted mice

• mice are protected from cardiac steatosis induced by prolonged fasting or feeding of a high-fat diet compared with wild-type mice

• however, mice exhibit normal levels in brown adipose tissue, soleus muscle and liver

homeostasis/metabolism

decreased cardiac muscle triglyceride level ( J:195987 )

• in the left ventricle of fasted mice

• mice are protected from cardiac steatosis induced by prolonged fasting or feeding of a high-fat diet compared with wild-type mice

• however, mice exhibit normal levels in brown adipose tissue, soleus muscle and liver

adipose tissue

adipose tissue phenotype ( J:195987 )

N	• mice exhibit normal adipose tissue differentiation and lipolysis in vitro and in vivo

Allelic Composition	Lep^ob/Lep^ob Plin4^tm1Vlcg/Plin4^tm1Vlcg
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lep^ob mutation (5 available); any Lep mutation (20 available)
Plin4^tm1Vlcg mutation (0 available); any Plin4 mutation (61 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased cardiac muscle triglyceride level ( J:195987 )

• mice are protected from cardiac steatosis

homeostasis/metabolism

decreased cardiac muscle triglyceride level ( J:195987 )

• mice are protected from cardiac steatosis

muscle

decreased cardiac muscle triglyceride level ( J:195987 )

• mice are protected from cardiac steatosis

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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