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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Plin2tm1.1Asg
targeted mutation 1.1, Andrew Greenberg
MGI:5502311
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Plin2tm1.1Asg/Plin2tm1.1Asg B6.129S2(Cg)-Plin2tm1.1Asg MGI:5502320


Genotype
MGI:5502320
hm1
Allelic
Composition
Plin2tm1.1Asg/Plin2tm1.1Asg
Genetic
Background
B6.129S2(Cg)-Plin2tm1.1Asg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plin2tm1.1Asg mutation (0 available); any Plin2 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• in mice fed a high fat diet
• in mice fed a high fat diet
• adipocytes in mice fed a high fat diet exhibit extensive areas of multilocular lipid droplets unlike in wild-type cells
• in the epididymal and subcutaneous fat pads of mice fed a high fat diet
• in mice fed a high fat diet
• epididymal and subcutaneous adipose tissue accumulate fewer crown-like structure macrophages enriched in lipid droplets compared to in wild-type tissue

homeostasis/metabolism
N
• mice fed a high fat diet exhibit normal energy expenditure as determined by respiratory exchange ratio
• in mice fed a high fat diet
• in mice fed a high fat diet
• in mice fed a high fat diet
• in mice fed a high fat diet
• in mice fed a high fat diet

behavior/neurological
• in mice fed a high fat diet
• in mice fed a high fat diet
• female mice exhibit difficulty raising their first litter
• however, subsequent pregnancies exhibit normal viability and growth rates

growth/size/body
• in mice fed a high fat diet
• in mice fed a high fat diet

liver/biliary system
• in mice fed a high fat diet

immune system
• epididymal and subcutaneous adipose tissue accumulate fewer crown-like structure macrophages enriched in lipid droplets compared to in wild-type tissue

integument
• in mice fed a high fat diet





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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory