All Phenotypes Trpv5<Hcalc1> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trpv5^Hcalc1/Trpv5^Hcalc1	involves: C3H/HeH * C57BL/6J	MGI:5501507
ht2	Trpv5^Hcalc1/Trpv5⁺	involves: C3H/HeH * C57BL/6J	MGI:5501506

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

increased renal tubule apoptosis ( J:196612 )

• in some male mice

increased urine calcium level ( J:196612 )

• at 16 weeks

decreased urine pH ( J:196612 )

increased urine phosphate level ( J:196612 )

kidney inflammation ( J:196612 )

• in some male mice

abnormal kidney morphology ( J:196612 )

• scarring in some male mice with small kidneys

renal interstitial fibrosis ( J:196612 )

• in some male mice

small kidney ( J:196612 )

• unilateral or bilateral in some male mice

abnormal renal tubule morphology ( J:196612 )

• some male mice exhibit the presence of numerous cells and/or cell debris within the dilated lumen of some cortical tubules

abnormal renal tubule epithelium morphology ( J:196612 )

• flattening of tubular epithelia in some male mice

dilated renal tubule ( J:196612 )

• in some male mice

polyuria ( J:196612 )

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:196612 )

N	• mice exhibit normal calcium serum levels

decreased circulating calcium level ( J:196612 )

• mild in female and male mice

decreased circulating phosphate level ( J:196612 )

• in female, but not male, mice

abnormal vitamin D level ( J:196612 )

• higher in the plasma in female and male mice

increased urine calcium level ( J:196612 )

• at 16 weeks

decreased urine pH ( J:196612 )

increased urine phosphate level ( J:196612 )

skeleton

abnormal bone structure ( J:196612 )

• elevated bone surface to volume ratio in female mice

decreased trabecular bone thickness ( J:196612 )

behavior/neurological

polydipsia ( J:196612 )

immune system

kidney inflammation ( J:196612 )

• in some male mice

cellular

increased renal tubule apoptosis ( J:196612 )

• in some male mice

Allelic Composition	Trpv5^Hcalc1/Trpv5⁺
Genetic Background	involves: C3H/HeH * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpv5^Hcalc1 mutation (0 available); any Trpv5 mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

increased renal tubule apoptosis ( J:196612 )

• in some male mice

increased urine calcium level ( J:196612 )

• at 16 weeks

kidney inflammation ( J:196612 )

• in some male mice

abnormal kidney morphology ( J:196612 )

• scarring in some male mice with small kidneys

renal interstitial fibrosis ( J:196612 )

• in some male mice

small kidney ( J:196612 )

• unilateral or bilateral in some male mice

abnormal renal tubule morphology ( J:196612 )

• some male mice exhibit the presence of numerous cells and/or cell debris within the dilated lumen of some cortical tubules

abnormal renal tubule epithelium morphology ( J:196612 )

• flattening of tubular epithelia in some male mice

dilated renal tubule ( J:196612 )

• in some male mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:196612 )

N	• mice exhibit normal calcium serum levels

increased urine calcium level ( J:196612 )

• at 16 weeks

immune system

kidney inflammation ( J:196612 )

• in some male mice

cellular

increased renal tubule apoptosis ( J:196612 )

• in some male mice

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