All Phenotypes Nkx6-1<tm1.1Msan> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nkx6-1^tm1.1Msan
targeted mutation 1.1, Maike Sander
MGI:5501129

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Nkx6-1^tm1Jlr/Nkx6-1^tm1.1Msan Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ Tg(Ins2-cre)25Mgn/0	involves: 129 * C57BL/6 * DBA * SJL	MGI:5501188
cn2	Nkx6-1^tm1Jlr/Nkx6-1^tm1.1Msan Tg(CAG-Bgeo/GFP)21Lbe/0 Tg(Neurog3-cre)C1Able/0	involves: 129/Sv * C57BL/6 * SJL	MGI:5501186
cn3	Nkx6-1^tm1.1Msan/Nkx6-1⁺ Pdx1^tm1Cvw/Pdx1⁺ Tg(Neurog3-cre)C1Able/0	involves: 129/Sv * C57BL/6 * SJL	MGI:5501187

Allelic Composition	Nkx6-1^tm1Jlr/Nkx6-1^tm1.1Msan Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ Tg(Ins2-cre)25Mgn/0
Genetic Background	involves: 129 * C57BL/6 * DBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1(EYFP)Cos mutation (11 available); any Gt(ROSA)26Sor mutation (942 available)
Nkx6-1^tm1.1Msan mutation (1 available); any Nkx6-1 mutation (4 available)
Nkx6-1^tm1Jlr mutation (0 available); any Nkx6-1 mutation (4 available)
Tg(Ins2-cre)25Mgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal pancreatic beta cell differentiation ( J:195153 )

• maintenance of beta cell is impaired with conversion to delta cell fate

decreased pancreatic beta cell number ( J:195153 )

increased pancreatic delta cell number ( J:195153 )

cellular

abnormal pancreatic beta cell differentiation ( J:195153 )

• maintenance of beta cell is impaired with conversion to delta cell fate

Allelic Composition	Nkx6-1^tm1Jlr/Nkx6-1^tm1.1Msan Tg(CAG-Bgeo/GFP)21Lbe/0 Tg(Neurog3-cre)C1Able/0
Genetic Background	involves: 129/Sv * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx6-1^tm1.1Msan mutation (1 available); any Nkx6-1 mutation (4 available)
Nkx6-1^tm1Jlr mutation (0 available); any Nkx6-1 mutation (4 available)
Tg(CAG-Bgeo/GFP)21Lbe mutation (2 available)
Tg(Neurog3-cre)C1Able mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:195153 )

• mice die within the first few days after birth

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:195153 )

N	• mice do not exhibit endocrine-to-acinar fate conversion • beta cells exhibit normal cell proliferation and apoptosis

abnormal pancreatic beta cell differentiation ( J:195153 )

• beta cell differentiation is impaired with insulin+ cells that are polyhormonal and ectopically express alpha cell markers unlike in control cells

increased pancreatic alpha cell number ( J:195153 )

decreased pancreatic beta cell number ( J:195153 )

• due to reduced differentiation without an effect on proliferation and apoptosis

increased pancreatic delta cell number ( J:195153 )

increased pancreatic epsilon cell number ( J:195153 )

homeostasis/metabolism

hyperglycemia ( J:195153 )

dehydration ( J:195153 )

cellular

abnormal pancreatic beta cell differentiation ( J:195153 )

• beta cell differentiation is impaired with insulin+ cells that are polyhormonal and ectopically express alpha cell markers unlike in control cells

Allelic Composition	Nkx6-1^tm1.1Msan/Nkx6-1⁺ Pdx1^tm1Cvw/Pdx1⁺ Tg(Neurog3-cre)C1Able/0
Genetic Background	involves: 129/Sv * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx6-1^tm1.1Msan mutation (1 available); any Nkx6-1 mutation (4 available)
Pdx1^tm1Cvw mutation (1 available); any Pdx1 mutation (35 available)
Tg(Neurog3-cre)C1Able mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:195153 )

• mice exhibit an increase in the glucagon to insulin cell ratio as in Pdx1^tm1Cvw heterozygotes

increased pancreatic alpha cell number ( J:195153 )

• as in Pdx1^tm1Cvw heterozygotes

decreased pancreatic beta cell number ( J:195153 )

• as in Pdx1^tm1Cvw heterozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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