All Phenotypes Dnase1l2<tm1.1(KOMP)Wtsi> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dnase1l2^{tm1.1(KOMP)Wtsi}
targeted mutation 1.1, Wellcome Trust Sanger Institute
MGI:5501065

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dnase1l2^{tm1.1(KOMP)Wtsi}/Dnase1l2^{tm1.1(KOMP)Wtsi}	C57BL/6N-Dnase1l2^{tm1.1(KOMP)Wtsi}/Bay	MGI:5898574
hm2	Dnase1l2^{tm1.1(KOMP)Wtsi}/Dnase1l2^{tm1.1(KOMP)Wtsi}	C57BL/6N-Dnase1l2^{tm1.1(KOMP)Wtsi}/H	MGI:5757009
hm3	Dnase1l2^{tm1.1(KOMP)Wtsi}/Dnase1l2^{tm1.1(KOMP)Wtsi}	C57BL/6N-Dnase1l2^{tm1.1(KOMP)Wtsi}/Ieg	MGI:5757008
hm4	Dnase1l2^{tm1.1(KOMP)Wtsi}/Dnase1l2^{tm1.1(KOMP)Wtsi}	C57BL/6N-Dnase1l2^{tm1.1(KOMP)Wtsi}/J	MGI:5757011
hm5	Dnase1l2^{tm1.1(KOMP)Wtsi}/Dnase1l2^{tm1.1(KOMP)Wtsi}	C57BL/6N-Dnase1l2^{tm1.1(KOMP)Wtsi}/Orl	MGI:5757010
hm6	Dnase1l2^{tm1.1(KOMP)Wtsi}/Dnase1l2^{tm1.1(KOMP)Wtsi}	C57BL/6N-Dnase1l2^{tm1.1(KOMP)Wtsi}/Ucd	MGI:5757007
hm7	Dnase1l2^{tm1.1(KOMP)Wtsi}/Dnase1l2^{tm1.1(KOMP)Wtsi}	C57BL/6N-Dnase1l2^{tm1.1(KOMP)Wtsi}/Wtsi	MGI:5757006
ht8	Dnase1l2^{tm1.1(KOMP)Wtsi}/Dnase1l2⁺	C57BL/6N-Dnase1l2^{tm1.1(KOMP)Wtsi}/Bay	MGI:5898573

Allelic Composition	Dnase1l2^{tm1.1(KOMP)Wtsi}/Dnase1l2^{tm1.1(KOMP)Wtsi}
Genetic Background	C57BL/6N-Dnase1l2^{tm1.1(KOMP)Wtsi}/Bay
Cell Lines	EPD0296_2_A10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnase1l2^{tm1.1(KOMP)Wtsi} mutation (2 available); any Dnase1l2 mutation (23 available)

Data Sources

IMPC Data for Dnase1l2

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased grip strength ( J:211773 )

IMPC - BCM

cardiovascular system

abnormal heart left ventricle morphology ( J:211773 )

IMPC - BCM

decreased cardiac stroke volume ( J:211773 )

IMPC - BCM

craniofacial

abnormal maxilla morphology ( J:211773 )

IMPC - BCM

hematopoietic system

abnormal spleen morphology ( J:211773 )

IMPC - BCM

immune system

abnormal spleen morphology ( J:211773 )

IMPC - BCM

limbs/digits/tail

brachydactyly ( J:211773 )

IMPC - BCM

short tibia ( J:211773 )

IMPC - BCM

skeleton

abnormal maxilla morphology ( J:211773 )

IMPC - BCM

short tibia ( J:211773 )

IMPC - BCM

abnormal joint morphology ( J:211773 )

IMPC - BCM

Allelic Composition	Dnase1l2^{tm1.1(KOMP)Wtsi}/Dnase1l2^{tm1.1(KOMP)Wtsi}
Genetic Background	C57BL/6N-Dnase1l2^{tm1.1(KOMP)Wtsi}/H
Cell Lines	EPD0296_2_A10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnase1l2^{tm1.1(KOMP)Wtsi} mutation (2 available); any Dnase1l2 mutation (23 available)

Data Sources

IMPC Data for Dnase1l2

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

decreased total body fat amount ( J:211773 )

IMPC - HAR

behavior/neurological

decreased grip strength ( J:211773 )

IMPC - HAR

decreased locomotor activity ( J:211773 )

IMPC - HAR

homeostasis/metabolism

increased blood urea nitrogen level ( J:211773 )

IMPC - HAR

limbs/digits/tail

abnormal digit morphology ( J:211773 )

IMPC - HAR

short tibia ( J:211773 )

IMPC - HAR

abnormal tail morphology ( J:211773 )

IMPC - HAR

skeleton

short tibia ( J:211773 )

IMPC - HAR

abnormal bone structure ( J:211773 )

IMPC - HAR

abnormal joint morphology ( J:211773 )

IMPC - HAR

vertebral fusion ( J:211773 )

IMPC - HAR

vision/eye

persistence of hyaloid vascular system ( J:211773 )

IMPC - HAR

Allelic Composition	Dnase1l2^{tm1.1(KOMP)Wtsi}/Dnase1l2^{tm1.1(KOMP)Wtsi}
Genetic Background	C57BL/6N-Dnase1l2^{tm1.1(KOMP)Wtsi}/Ieg
Cell Lines	EPD0296_2_A10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnase1l2^{tm1.1(KOMP)Wtsi} mutation (2 available); any Dnase1l2 mutation (23 available)

Data Sources

IMPC Data for Dnase1l2

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased locomotor activity ( J:211773 )

IMPC - HMGU

abnormal vocalization ( J:211773 )

IMPC - HMGU

growth/size/body

decreased body length ( J:211773 )

IMPC - HMGU

homeostasis/metabolism

increased blood urea nitrogen level ( J:211773 )

IMPC - HMGU

increased fasting circulating glucose level ( J:211773 )

IMPC - HMGU

limbs/digits/tail

abnormal autopod morphology ( J:211773 )

IMPC - HMGU

abnormal digit morphology ( J:211773 )

IMPC - HMGU

short tibia ( J:211773 )

IMPC - HMGU

nervous system

abnormal optic disk morphology ( J:211773 )

IMPC - HMGU

skeleton

short tibia ( J:211773 )

IMPC - HMGU

vision/eye

abnormal optic disk morphology ( J:211773 )

IMPC - HMGU

abnormal lens morphology ( J:211773 )

IMPC - HMGU

Allelic Composition	Dnase1l2^{tm1.1(KOMP)Wtsi}/Dnase1l2^{tm1.1(KOMP)Wtsi}
Genetic Background	C57BL/6N-Dnase1l2^{tm1.1(KOMP)Wtsi}/J
Cell Lines	EPD0296_2_A10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnase1l2^{tm1.1(KOMP)Wtsi} mutation (2 available); any Dnase1l2 mutation (23 available)

Data Sources

IMPC Data for Dnase1l2

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

increased heart weight ( J:211773 )

IMPC - JAX

growth/size/body

increased heart weight ( J:211773 )

IMPC - JAX

decreased body length ( J:211773 )

IMPC - JAX

homeostasis/metabolism

increased fasting circulating glucose level ( J:211773 )

IMPC - JAX

Allelic Composition	Dnase1l2^{tm1.1(KOMP)Wtsi}/Dnase1l2^{tm1.1(KOMP)Wtsi}
Genetic Background	C57BL/6N-Dnase1l2^{tm1.1(KOMP)Wtsi}/Orl
Cell Lines	EPD0296_2_A10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnase1l2^{tm1.1(KOMP)Wtsi} mutation (2 available); any Dnase1l2 mutation (23 available)

Data Sources

IMPC Data for Dnase1l2

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:211773 )

IMPC - ICS

decreased grip strength ( J:211773 )

IMPC - ICS

decreased locomotor activity ( J:211773 )

IMPC - ICS

growth/size/body

abnormal head morphology ( J:211773 )

IMPC - ICS

decreased body length ( J:211773 )

IMPC - ICS

homeostasis/metabolism

increased circulating calcium level ( J:211773 )

IMPC - ICS

integument

abnormal nail morphology ( J:211773 )

IMPC - ICS

limbs/digits/tail

abnormal digit morphology ( J:211773 )

IMPC - ICS

short tibia ( J:211773 )

IMPC - ICS

abnormal tail morphology ( J:211773 )

IMPC - ICS

skeleton

short tibia ( J:211773 )

IMPC - ICS

vision/eye

persistence of hyaloid vascular system ( J:211773 )

IMPC - ICS

Allelic Composition	Dnase1l2^{tm1.1(KOMP)Wtsi}/Dnase1l2^{tm1.1(KOMP)Wtsi}
Genetic Background	C57BL/6N-Dnase1l2^{tm1.1(KOMP)Wtsi}/Ucd
Cell Lines	EPD0296_2_A10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnase1l2^{tm1.1(KOMP)Wtsi} mutation (2 available); any Dnase1l2 mutation (23 available)

Data Sources

IMPC Data for Dnase1l2

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

decreased total body fat amount ( J:211773 )

IMPC - TCP

behavior/neurological

decreased grip strength ( J:211773 )

IMPC - TCP

craniofacial

abnormal cranium morphology ( J:211773 )

IMPC - TCP

growth/size/body

decreased body length ( J:211773 )

IMPC - TCP

limbs/digits/tail

abnormal digit morphology ( J:211773 )

IMPC - TCP

brachydactyly ( J:211773 )

IMPC - TCP

short tibia ( J:211773 )

IMPC - TCP

nervous system

abnormal optic disk morphology ( J:211773 )

IMPC - TCP

skeleton

abnormal cranium morphology ( J:211773 )

IMPC - TCP

short tibia ( J:211773 )

IMPC - TCP

abnormal bone structure ( J:211773 )

IMPC - TCP

decreased bone mineral content ( J:211773 )

IMPC - TCP

vision/eye

abnormal eye morphology ( J:211773 )

IMPC - TCP

abnormal optic disk morphology ( J:211773 )

IMPC - TCP

Allelic Composition	Dnase1l2^{tm1.1(KOMP)Wtsi}/Dnase1l2^{tm1.1(KOMP)Wtsi}
Genetic Background	C57BL/6N-Dnase1l2^{tm1.1(KOMP)Wtsi}/Wtsi
Cell Lines	EPD0296_2_A10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnase1l2^{tm1.1(KOMP)Wtsi} mutation (2 available); any Dnase1l2 mutation (23 available)

Data Sources

IMPC Data for Dnase1l2

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

decreased total body fat amount ( J:211773 )

IMPC - UCD

increased total body fat amount ( J:211773 )

IMPC - WTSI

behavior/neurological

decreased grip strength ( J:211773 )

IMPC - WTSI

cardiovascular system

eye hemorrhage ( J:211773 )

IMPC - UCD

growth/size/body

decreased lean body mass ( J:211773 )

IMPC - WTSI

decreased body length ( J:211773 )

IMPC - WTSI

homeostasis/metabolism

increased circulating aspartate transaminase level ( J:211773 )

IMPC - WTSI

limbs/digits/tail

abnormal digit morphology ( J:211773 )

IMPC - WTSI

abnormal tibia morphology ( J:211773 )

IMPC - WTSI

short tibia ( J:211773 )

IMPC - UCD

abnormal tail morphology ( J:211773 )

IMPC - WTSI

skeleton

abnormal tibia morphology ( J:211773 )

IMPC - WTSI

short tibia ( J:211773 )

IMPC - UCD

abnormal spine curvature ( J:211773 )

IMPC - WTSI

abnormal bone structure ( J:211773 )

IMPC - UCD

decreased bone mineral content ( J:211773 )

IMPC - WTSI

abnormal joint morphology ( J:211773 )

IMPC - WTSI

fusion of vertebral arches ( J:211773 )

IMPC - WTSI

vision/eye

eye hemorrhage ( J:211773 )

IMPC - UCD

Allelic Composition	Dnase1l2^{tm1.1(KOMP)Wtsi}/Dnase1l2⁺
Genetic Background	C57BL/6N-Dnase1l2^{tm1.1(KOMP)Wtsi}/Bay
Cell Lines	EPD0296_2_A10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnase1l2^{tm1.1(KOMP)Wtsi} mutation (2 available); any Dnase1l2 mutation (23 available)

Data Sources

IMPC Data for Dnase1l2

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal stomach morphology ( J:211773 )

IMPC - BCM

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23