All Phenotypes Lin28a<tm1.1Gqda> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lin28a^tm1.1Gqda
targeted mutation 1.1, George Q Daley
MGI:5500060

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lin28a^tm1.1Gqda/Lin28a^tm1.1Gqda	involves: 129S4/SvJae * C57BL/6	MGI:5519074
hm2	Lin28a^tm1.1Gqda/Lin28a^tm1.1Gqda	involves: 129S4/SvJae * C57BL/6 * FVB	MGI:5500064
cn3	Lin28a^tm1Gqda/Lin28a^tm1.1Gqda Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0	involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N	MGI:5519072
cx4	Lin28a^tm1.1Gqda/Lin28a⁺ Lin28b^tm1.1Gqda/Lin28b^tm1.1Gqda	involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N	MGI:5519070
cx5	Lin28a^tm1.1Gqda/Lin28a^tm1.1Gqda Lin28b^tm1.1Gqda/Lin28b^tm1.1Gqda	involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N	MGI:5519071
cx6	Lin28a^tm1.1Gqda/Lin28a^tm1.1Gqda Tsc1^tm1.1Djk/Tsc1⁺	involves: 129S4/SvJae * C57BL/6	MGI:5519079

Allelic Composition	Lin28a^tm1.1Gqda/Lin28a^tm1.1Gqda
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lin28a^tm1.1Gqda mutation (1 available); any Lin28a mutation (78 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:199720 )

• nearly all mice die within 1 day of birth

growth/size/body

decreased embryo weight ( J:199720 )

• dwarfism at E13.5

decreased body size ( J:199720 )

• in surviving mice

decreased body weight ( J:199720 )

• in surviving mice

decreased body length ( J:199720 )

• in surviving mice

decreased fetal weight ( J:199720 )

• at E18.5

homeostasis/metabolism

abnormal glucose homeostasis ( J:199720 )

• lower flux in glycolysis at E10.5

cellular

abnormal cell physiology ( J:199720 )

• dysregulation of pyrimidine metabolism at E10.5

adipose tissue

decreased total body fat amount ( J:199720 )

• severe in surviving mice

cardiovascular system

ventricular septal defect ( J:199720 )

skeleton

decreased bone mineral density ( J:199720 )

• in surviving mice

embryo

decreased embryo weight ( J:199720 )

• dwarfism at E13.5

muscle

muscle phenotype ( J:199720 )

N	• mice exhibit normal muscle histology

Allelic Composition	Lin28a^tm1.1Gqda/Lin28a^tm1.1Gqda
Genetic Background	involves: 129S4/SvJae * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lin28a^tm1.1Gqda mutation (1 available); any Lin28a mutation (78 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

decreased germ cell number ( J:196313 )

• in neonates

reduced fertility ( J:196313 )

cellular

decreased germ cell number ( J:196313 )

• in neonates

Allelic Composition	Lin28a^tm1Gqda/Lin28a^tm1.1Gqda Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0
Genetic Background	involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lin28a^tm1.1Gqda mutation (1 available); any Lin28a mutation (78 available)
Lin28a^tm1Gqda mutation (0 available); any Lin28a mutation (78 available)
Ndor1^{Tg(UBC-cre/ERT2)1Ejb} mutation (11 available); any Ndor1 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:199720 )

N	• mice exhibit normal growth when treated with tamoxifen at 7 to 9 days or 6 weeks of age

decreased body size ( J:199720 )

• dwarfism in male mice treated with tamoxifen at E15.5, but not as severe as in Lin28a^tm1.1Gqda homozygotes

• however, female mice exhibit normal growth

decreased body length ( J:199720 )

• dwarfism in male mice treated with tamoxifen at E15.5

• however, female mice exhibit normal growth

Allelic Composition	Lin28a^tm1.1Gqda/Lin28a⁺ Lin28b^tm1.1Gqda/Lin28b^tm1.1Gqda
Genetic Background	involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lin28a^tm1.1Gqda mutation (1 available); any Lin28a mutation (78 available)
Lin28b^tm1.1Gqda mutation (1 available); any Lin28b mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:199720 )

• dwarfism in female and male mice

Allelic Composition	Lin28a^tm1.1Gqda/Lin28a^tm1.1Gqda Lin28b^tm1.1Gqda/Lin28b^tm1.1Gqda
Genetic Background	involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:199720 )

• mice die between E10.5 and E12.5

nervous system

open neural tube ( J:199720 )

• in 2 of 7 at E11.5

abnormal forebrain development ( J:199720 )

• poor development

collapsed brain ventricles ( J:199720 )

• collapsed ventricle

growth/size/body

embryonic growth retardation ( J:199720 )

• indicated by fewer somites at E10.5 and open neural tube in some mice at E11.5

decreased embryo size ( J:199720 )

• at E9.5 and E10.5

embryo

embryonic growth retardation ( J:199720 )

• indicated by fewer somites at E10.5 and open neural tube in some mice at E11.5

decreased embryo size ( J:199720 )

• at E9.5 and E10.5

open neural tube ( J:199720 )

• in 2 of 7 at E11.5

Allelic Composition	Lin28a^tm1.1Gqda/Lin28a^tm1.1Gqda Tsc1^tm1.1Djk/Tsc1⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lin28a^tm1.1Gqda mutation (1 available); any Lin28a mutation (78 available)
Tsc1^tm1.1Djk mutation (0 available); any Tsc1 mutation (68 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:199720 )

• as in Lin28a^tm1.1Gqda homozygotes

growth/size/body

decreased body size ( J:199720 )

• dwarfism as in Lin28a^tm1.1Gqda homozygotes

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