About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ilktm2Star
targeted mutation 2, Rene St-Arnaud
MGI:5499793
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ilktm1Star/Ilktm2Star
Tg(Acp5-cre)1Star/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5502225
cx2
 		Ilktm2Star/Ilk+
Itgb3tm1Hyn/Itgb3+ 		involves: 129S2/SvPas * C57BL/6 MGI:5502226


Genotype
MGI:5502225
cn1
Allelic
Composition		 Ilktm1Star/Ilktm2Star
Tg(Acp5-cre)1Star/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ilktm1Star mutation (1 available); any Ilk mutation (18 available)
Ilktm2Star mutation (0 available); any Ilk mutation (18 available)
Tg(Acp5-cre)1Star mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
growth/size/body region phenotype ( J:197593 )
N
• mice are phenotypically normal and show no differences in size or weight relative to controls at birth or throughout their lifespan

craniofacial
craniofacial phenotype ( J:197593 )
N
• animals have normal tooth eruption

skeleton
increased osteoclast cell number ( J:197593 )
• numbers of osteoclasts in the primary spongiosa are significantly increased at 6 weeks
abnormal osteoclast physiology ( J:197593 )
• in vitro differentiated osteoclasts plate on dentin slices display decreased bone resorpion activity (45% lower osteoclastic resorption activity); osteoclasts show impaired resorption in vivo also
increased bone volume ( J:197593 )
• tibial bone volume is increased by 24% compared to controls at 6 weeks
increased trabecular bone thickness ( J:197593 )
• trabecular thickness of tibiae at 6 weeks is increased by 44% compared to controls

hematopoietic system
increased osteoclast cell number ( J:197593 )
• numbers of osteoclasts in the primary spongiosa are significantly increased at 6 weeks
abnormal osteoclast physiology ( J:197593 )
• in vitro differentiated osteoclasts plate on dentin slices display decreased bone resorpion activity (45% lower osteoclastic resorption activity); osteoclasts show impaired resorption in vivo also

immune system
increased osteoclast cell number ( J:197593 )
• numbers of osteoclasts in the primary spongiosa are significantly increased at 6 weeks
abnormal osteoclast physiology ( J:197593 )
• in vitro differentiated osteoclasts plate on dentin slices display decreased bone resorpion activity (45% lower osteoclastic resorption activity); osteoclasts show impaired resorption in vivo also




Genotype
MGI:5502226
cx2
Allelic
Composition		 Ilktm2Star/Ilk+
Itgb3tm1Hyn/Itgb3+
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ilktm2Star mutation (0 available); any Ilk mutation (18 available)
Itgb3tm1Hyn mutation (6 available); any Itgb3 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
increased trabecular bone thickness ( J:197593 )
• mice display significant increase in thickness of the trabeculae at the primary spongiosa




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory