Phenotypes associated with this allele

• Allele Symbol: Kdm6a^tm1.1Afst
• Allele Name: targeted mutation 1.1, A Stewart
• Allele ID: MGI:5499290
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Kdm6a^tm1.1Afst/Kdm6a^tm1.1Afst Gt(ROSA)26Sor^tm9(cre/ESR1)Arte/Gt(ROSA)26Sor^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac	MGI:5499565
cn2	Kdm6a^tm1.1Afst/Y Gt(ROSA)26Sor^tm9(cre/ESR1)Arte/Gt(ROSA)26Sor^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac	MGI:5499566

Genotype
MGI:5499565

cn1

• Allelic Composition: Kdm6a^tm1.1Afst/Kdm6a^tm1.1Afst; Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

enlarged spleen ( J:196401 )

♀ • in tamoxifen-treated mice

increased spleen weight ( J:196401 )

♀ • in tamoxifen-treated mice

abnormal erythropoiesis ( J:196401 )

♀ • in the spleen of tamoxifen-treated mice

extramedullary hematopoiesis ( J:196401 )

♀ • in tamoxifen-treated mice

anemia ( J:196401 )

♀ • anemic appearance of the bones in tamoxifen-treated mice

abnormal bone marrow cell morphology/development ( J:196401 )

♀ • tamoxifen-treated mice exhibit disturbed cell distribution with pronounced dysplasia and disrupted maturation in the erythroid, megakaryocytic and granulocytic lineages compared with control mice

♀ • bone marrow from tamoxifen-treated mice exhibit reduced formation of colony forming units compared with control mice

♀ • however, tamoxifen-treated mice exhibit normal numbers of hematopoietic stem cells

decreased common myeloid progenitor cell number ( J:196401 )

♀ • decreased granulocyte-macrophage progenitors and macrophage colony numbers from bone marrow of tamoxifen-treated mice

abnormal megakaryocyte morphology ( J:196401 )

♀ • abnormal nuclear lobation and atypical mitosis in tamoxifen-treated mice

decreased erythroid progenitor cell number ( J:196401 )

♀ • in tamoxifen-treated mice

decreased erythrocyte cell number ( J:196401 )

♀ • in tamoxifen-treated mice

decreased hemoglobin content ( J:196401 )

♀ • in tamoxifen-treated mice

decreased mean corpuscular volume ( J:196401 )

♀ • in tamoxifen-treated mice

abnormal granulocyte morphology ( J:196401 )

♀ • dysplastic granulocytes with nuclear hyposegmentation in tamoxifen-treated mice

thrombocytopenia ( J:196401 )

♀ • in tamoxifen-treated mice

increased B cell number ( J:196401 )

♀ • in the spleen of tamoxifen-treated mice

decreased leukocyte cell number ( J:196401 )

♀ • relative in tamoxifen-treated mice

abnormal hematopoietic stem cell physiology ( J:196401 )

♀ • impaired migration in hematopoietic stem and progenitor cells of tamoxifen-treated mice

cellular

spontaneous chromosome breakage ( J:196401 )

♀ • increased chromosomal double-strand breaks and numerical and structural chromosomal aberrations 2 weeks after tamoxifen-treatment

growth/size/body

weight loss ( J:196401 )

♀ • in tamoxifen-treated mice

enlarged spleen ( J:196401 )

♀ • in tamoxifen-treated mice

increased spleen weight ( J:196401 )

♀ • in tamoxifen-treated mice

skeleton

abnormal bone structure ( J:196401 )

♀ • anemic appearance of the bones in tamoxifen-treated mice

immune system

enlarged spleen ( J:196401 )

♀ • in tamoxifen-treated mice

increased spleen weight ( J:196401 )

♀ • in tamoxifen-treated mice

abnormal granulocyte morphology ( J:196401 )

♀ • dysplastic granulocytes with nuclear hyposegmentation in tamoxifen-treated mice

increased B cell number ( J:196401 )

♀ • in the spleen of tamoxifen-treated mice

decreased leukocyte cell number ( J:196401 )

♀ • relative in tamoxifen-treated mice

Genotype
MGI:5499566

cn2

• Allelic Composition: Kdm6a^tm1.1Afst/Y; Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac

hematopoietic system

hematopoietic system phenotype ( J:196401 )

♂N • tamoxifen-treated mice exhibit normal blood counts