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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pik3r4tm1.1Mpnd
targeted mutation 1.1, Mario Pende
MGI:5499157
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pik3r4tm1.1Mpnd/Pik3r4tm1.1Mpnd involves: 129S2/SvPas * C57BL/6N MGI:5499164
cn2
 		Pik3r4tm1.1Mpnd/Pik3r4tm1.1Mpnd involves: 129S2/SvPas * C57BL/6 MGI:6331086
cn3
 		Pik3r4tm1.1Mpnd/Pik3r4tm1.1Mpnd involves: 129S2/SvPas * C57BL/6N MGI:5499165
cn4
 		Neurod6tm1(cre)Kan/Neurod6+
Pik3r4mbe/Pik3r4tm1.1Mpnd 		involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C3H/HeH * C57BL/6 MGI:6331081
cn5
 		Pik3r4mbe/Pik3r4tm1.1Mpnd
Emx1tm1(cre)Krj/Emx1+ 		involves: 129S2/SvPas * C3H/HeH * C57BL/6 MGI:6331079
cn6
 		Pik3r4tm1.1Mpnd/Pik3r4tm1.1Mpnd
Emx1tm1(cre)Krj/Emx1+ 		involves: 129S2/SvPas * C57BL/6 MGI:6331087
cn7
 		Pik3r4tm1.1Mpnd/Pik3r4tm1.1Mpnd
Tg(ACTA1-cre)79Jme/0 		involves: 129S2/SvPas * C57BL/6J * C57BL/6N * SJL MGI:5499166


Genotype
MGI:5499164
hm1
Allelic
Composition		 Pik3r4tm1.1Mpnd/Pik3r4tm1.1Mpnd
Genetic
Background		 involves: 129S2/SvPas * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3r4tm1.1Mpnd mutation (1 available); any Pik3r4 mutation (62 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:198770 )
• mice are viable and fertile and do not present any overt phenotype




Genotype
MGI:6331086
cn2
Allelic
Composition		 Pik3r4tm1.1Mpnd/Pik3r4tm1.1Mpnd
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3r4tm1.1Mpnd mutation (1 available); any Pik3r4 mutation (62 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal neuronal migration ( J:258027 )
• in utero electroporation with a cre recombinase at E14.5 causes a severe cortical neuronal migration defect

nervous system
abnormal neuronal migration ( J:258027 )
• in utero electroporation with a cre recombinase at E14.5 causes a severe cortical neuronal migration defect




Genotype
MGI:5499165
cn3
Allelic
Composition		 Pik3r4tm1.1Mpnd/Pik3r4tm1.1Mpnd
Genetic
Background		 involves: 129S2/SvPas * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3r4tm1.1Mpnd mutation (1 available); any Pik3r4 mutation (62 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal autophagy ( J:198770 )
• mouse embryonic fibroblasts treated with a cre-expressing adenovirus exhibit compromised autophagy flux compared with control cells
• however, treated MEFs exhibit normal autophagosome formation

homeostasis/metabolism
abnormal autophagy ( J:198770 )
• mouse embryonic fibroblasts treated with a cre-expressing adenovirus exhibit compromised autophagy flux compared with control cells
• however, treated MEFs exhibit normal autophagosome formation




Genotype
MGI:6331081
cn4
Allelic
Composition		 Neurod6tm1(cre)Kan/Neurod6+
Pik3r4mbe/Pik3r4tm1.1Mpnd
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C3H/HeH * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neurod6tm1(cre)Kan mutation (0 available); any Neurod6 mutation (17 available)
Pik3r4mbe mutation (0 available); any Pik3r4 mutation (62 available)
Pik3r4tm1.1Mpnd mutation (1 available); any Pik3r4 mutation (62 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal hippocampus pyramidal cell layer ( J:258027 )
• pyramidal cell layer is fractured
ectopic hippocampus pyramidal cells ( J:258027 )
• increase in the number of ectopic pyramidal cells in the stratum oriens layer
abnormal hippocampus stratum oriens morphology ( J:258027 )
• the stratum oriens layer contains ectopic pyramidal cells




Genotype
MGI:6331079
cn5
Allelic
Composition		 Pik3r4mbe/Pik3r4tm1.1Mpnd
Emx1tm1(cre)Krj/Emx1+
Genetic
Background		 involves: 129S2/SvPas * C3H/HeH * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1(cre)Krj mutation (2 available); any Emx1 mutation (34 available)
Pik3r4mbe mutation (0 available); any Pik3r4 mutation (62 available)
Pik3r4tm1.1Mpnd mutation (1 available); any Pik3r4 mutation (62 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal hippocampus pyramidal cell layer ( J:258027 )
• pyramidal cell layer is fractured
ectopic hippocampus pyramidal cells ( J:258027 )
• increase in the number of ectopic pyramidal cells in the stratum oriens layer
abnormal hippocampus stratum oriens morphology ( J:258027 )
• the stratum oriens layer contains ectopic pyramidal cells




Genotype
MGI:6331087
cn6
Allelic
Composition		 Pik3r4tm1.1Mpnd/Pik3r4tm1.1Mpnd
Emx1tm1(cre)Krj/Emx1+
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1(cre)Krj mutation (2 available); any Emx1 mutation (34 available)
Pik3r4tm1.1Mpnd mutation (1 available); any Pik3r4 mutation (62 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal hippocampus morphology ( J:258027 )
• the hippocampus is barely discernible, with no structured pyramidal cell layer or dentate gyrus at P0 and P11
• the severe, progressive degeneration of the hippocampus is associated with caspase-induced apoptosis
abnormal cerebral cortex morphology ( J:258027 )
• severe, progressive degeneration of the cortex that is associated with caspase-induced apoptosis
thin cerebral cortex ( J:258027 )
• reduction in cortical thickness at P0 that is more severe at P11




Genotype
MGI:5499166
cn7
Allelic
Composition		 Pik3r4tm1.1Mpnd/Pik3r4tm1.1Mpnd
Tg(ACTA1-cre)79Jme/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6J * C57BL/6N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3r4tm1.1Mpnd mutation (1 available); any Pik3r4 mutation (62 available)
Tg(ACTA1-cre)79Jme mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
skeletal muscle fiber necrosis ( J:198770 )
• as early as 2 months of age
increased skeletal muscle glycogen level ( J:198770 )
• as early as 2 months of age
myositis ( J:198770 )
• as early as 2 months of age
centrally nucleated skeletal muscle fibers ( J:198770 )
• as early as 2 months of age
skeletal muscle degeneration ( J:198770 )
• severe muscular degeneration (with necrotic fibers, cell infiltration and centronucleated fibers) as early as 2 months of age
• more pronounced in fast twitch muscles compared to in mice with muscle-specific knock-out of Atg7tm1Tchi
muscle weakness ( J:198770 )
• reduced force from the gastrocnemius of mice subjected to stimulation of the sciatic nerve
myopathy ( J:198770 )
• mice display symptoms of autophagic vacuolar myopathies

cellular
abnormal autophagy ( J:198770 )
• compromised in muscles with accumulation of autophagosomes and lysosomes
skeletal muscle fiber necrosis ( J:198770 )
• as early as 2 months of age

homeostasis/metabolism
abnormal autophagy ( J:198770 )
• compromised in muscles with accumulation of autophagosomes and lysosomes
increased skeletal muscle glycogen level ( J:198770 )
• as early as 2 months of age

immune system
myositis ( J:198770 )
• as early as 2 months of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory