Pik3r4^tm1.1Mpnd
Targeted Allele Detail

Summary

• Symbol: Pik3r4^tm1.1Mpnd
• Name: phosphoinositide-3-kinase regulatory subunit 4; targeted mutation 1.1, Mario Pende
• MGI ID: MGI:5499157
• Synonyms: Vps15^f
• Gene: Pik3r4 Location: Chr9:105520177-105564856 bp, + strand Genetic Position: Chr9, 56.79 cM, cytoband F1
• Alliance: Pik3r4^tm1.1Mpnd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198770
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a loxP site upstream of exon 2, and a second loxP site followed by a FRT-flanked neomycin resistance (neo) cassette, downstream of exon 2. Flp-mediated recombination removed the neo cassette. (J:198770)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pik3r4 Mutation: 62 strains or lines available

References

• Original: J:198770 Nemazanyy I, et al., Defects of Vps15 in skeletal muscles lead to autophagic vacuolar myopathy and lysosomal disease. EMBO Mol Med. 2013 Jun;5(6):870-90
• All: 5 reference(s)