Phenotypes associated with this allele

• Allele Symbol: Epx^{tm1.1(cre)Jlee}
• Allele Name: targeted mutation 1.1, James J Lee
• Allele ID: MGI:5498555
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Epx^tm1.1(cre)Jlee/Epx^tm1.1(cre)Jlee	B6.Cg-Epx^tm1.1(cre)Jlee/Jlee	MGI:6432800
cn2	Epx^tm1.1(cre)Jlee/Epx^+ Gt(ROSA)26Sor^tm1(DTA)Lky/Gt(ROSA)26Sor^+	involves: 129P2/OlaHsd * C57BL/6	MGI:5500049

Genotype
MGI:6432800

hm1

• Allelic Composition: Epx^{tm1.1(cre)Jlee}/Epx^{tm1.1(cre)Jlee}
• Genetic Background: B6.Cg-Epx^{tm1.1(cre)Jlee}/Jlee

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:198489 )

N • mice exhibit normal numbers of eosinophils in the peripheral blood and bone marrow

Genotype
MGI:5500049

cn2

• Allelic Composition: Epx^{tm1.1(cre)Jlee}/Epx⁺; Gt(ROSA)26Sor^tm1(DTA)Lky/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

hematopoietic system

decreased eosinophil cell number ( J:198489 )

• peripheral blood is deficient in eosinophils relative to wild-type (0.19% vs 1.85%)

• other non-eosinophilic circulating cell populations are unchanged in cell number and relative composition in mutants

immune system

decreased eosinophil cell number ( J:198489 )

• peripheral blood is deficient in eosinophils relative to wild-type (0.19% vs 1.85%)

• other non-eosinophilic circulating cell populations are unchanged in cell number and relative composition in mutants