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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Epxtm1.1(cre)Jlee
targeted mutation 1.1, James J Lee
MGI:5498555
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Epxtm1.1(cre)Jlee/Epxtm1.1(cre)Jlee B6.Cg-Epxtm1.1(cre)Jlee/Jlee MGI:6432800
cn2
 		Epxtm1.1(cre)Jlee/Epx+
Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:5500049


Genotype
MGI:6432800
hm1
Allelic
Composition		 Epxtm1.1(cre)Jlee/Epxtm1.1(cre)Jlee
Genetic
Background		 B6.Cg-Epxtm1.1(cre)Jlee/Jlee
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epxtm1.1(cre)Jlee mutation (0 available); any Epx mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:198489 )
N
• mice exhibit normal numbers of eosinophils in the peripheral blood and bone marrow




Genotype
MGI:5500049
cn2
Allelic
Composition		 Epxtm1.1(cre)Jlee/Epx+
Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epxtm1.1(cre)Jlee mutation (0 available); any Epx mutation (34 available)
Gt(ROSA)26Sortm1(DTA)Lky mutation (3 available); any Gt(ROSA)26Sor mutation (944 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased eosinophil cell number ( J:198489 )
• peripheral blood is deficient in eosinophils relative to wild-type (0.19% vs 1.85%)
• other non-eosinophilic circulating cell populations are unchanged in cell number and relative composition in mutants

immune system
decreased eosinophil cell number ( J:198489 )
• peripheral blood is deficient in eosinophils relative to wild-type (0.19% vs 1.85%)
• other non-eosinophilic circulating cell populations are unchanged in cell number and relative composition in mutants




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory