Phenotypes associated with this allele

• Allele Symbol: Twnk^tm1.1Lrsn
• Allele Name: targeted mutation 1.1, Nils-Goran Larsson
• Allele ID: MGI:5496874
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Twnk^tm1.1Lrsn/Twnk^tm1.1Lrsn Tg(Ckmm-cre)5Khn/0	involves: C57BL/6 * FVB	MGI:5496891

Genotype
MGI:5496891

cn1

• Allelic Composition: Twnk^tm1.1Lrsn/Twnk^tm1.1Lrsn; Tg(Ckmm-cre)5Khn/0
• Genetic Background: involves: C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:194965 )

• mice die at 19 weeks

cardiovascular system

enlarged heart ( J:194965 )

• mice show signs of progressive heart enlargement from age of 8 weeks

cellular

abnormal mitochondrial morphology ( J:194965 )

• severe depletion of mitochondrial DNA (mtDNA) is observed in heart-specific mutants; this results in decrease of mtDNA-encoded transcripts and mtDNA-encoded proteins like Cox1 and Cox2

abnormal respiratory electron transport chain ( J:194965 )

• in heart tissue, levels respiratory complexes and superassemblies containing mtDNA-encoded subunits are decreased complared to an exclusively nucleus-encoded complex indicating that the mutation results in defective respiratory chain assembly in heart mitochondria

growth/size/body

enlarged heart ( J:194965 )

• mice show signs of progressive heart enlargement from age of 8 weeks