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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(HBB)8.1Gvs
transgene insertion 8.1, Frank Grosveld
MGI:5496829
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Bcl11atm1Mbu/Bcl11atm1Mbu
Eportm1.1(EGFP/icre)Uk/Epor+
Tg(HBB)8.1Gvs/0 		involves: 129 * BALB/cJ * FVB/N MGI:5496871
cn2
 		Bcl11atm1Mbu/Bcl11atm1Mbu
Klf1tm1Nimr/Klf1+
Eportm1.1(EGFP/icre)Uk/Epor+
Tg(HBB)8.1Gvs/0 		involves: 129P2/OlaHsd * BALB/cJ * FVB/N MGI:5496872
cn3
 		Bcl11atm1Mbu/Bcl11atm1Mbu
Klf1tm1Nimr/Klf1+
Tg(HBB)8.1Gvs/0 		involves: 129P2/OlaHsd * FVB MGI:5496870


Genotype
MGI:5496871
cn1
Allelic
Composition		 Bcl11atm1Mbu/Bcl11atm1Mbu
Eportm1.1(EGFP/icre)Uk/Epor+
Tg(HBB)8.1Gvs/0
Genetic
Background		 involves: 129 * BALB/cJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl11atm1Mbu mutation (0 available); any Bcl11a mutation (42 available)
Eportm1.1(EGFP/icre)Uk mutation (2 available); any Epor mutation (25 available)
Tg(HBB)8.1Gvs mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:196405 )
N
• mice are produced in expected Mendelian ratios

hematopoietic system
abnormal erythropoiesis ( J:196405 )
• increased Ter119+/CD71+ cells in the blood
• increased Ter119+/DRAQ5+ cells in the blood
anemia ( J:196405 )
• mild

homeostasis/metabolism
increased circulating erythropoietin level ( J:196405 )
• indicating anemic stress




Genotype
MGI:5496872
cn2
Allelic
Composition		 Bcl11atm1Mbu/Bcl11atm1Mbu
Klf1tm1Nimr/Klf1+
Eportm1.1(EGFP/icre)Uk/Epor+
Tg(HBB)8.1Gvs/0
Genetic
Background		 involves: 129P2/OlaHsd * BALB/cJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl11atm1Mbu mutation (0 available); any Bcl11a mutation (42 available)
Eportm1.1(EGFP/icre)Uk mutation (2 available); any Epor mutation (25 available)
Klf1tm1Nimr mutation (0 available); any Klf1 mutation (22 available)
Tg(HBB)8.1Gvs mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal erythropoiesis ( J:196405 )
• increased Ter119+/CD71+ cells in the blood




Genotype
MGI:5496870
cn3
Allelic
Composition		 Bcl11atm1Mbu/Bcl11atm1Mbu
Klf1tm1Nimr/Klf1+
Tg(HBB)8.1Gvs/0
Genetic
Background		 involves: 129P2/OlaHsd * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl11atm1Mbu mutation (0 available); any Bcl11a mutation (42 available)
Klf1tm1Nimr mutation (0 available); any Klf1 mutation (22 available)
Tg(HBB)8.1Gvs mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:196405 )
N
• mice are produced in expected Mendelian ratios

hematopoietic system
abnormal erythropoiesis ( J:196405 )
• increased CD71-/Ter119+ cells in the blood and liver at E18.5
• increased Ter119+/CD71+ cells in the blood
• increased Ter119+/DRAQ5+ cells in the blood
anemia ( J:196405 )
• mild
decreased erythrocyte cell number ( J:196405 )
• more pronounced than in Bcl11atm1Phi/Bcl11atm1Phi Eportm1(EGFP/cre)Uk/Epor+ Tg(HBB)8.1Gvs mice
decreased hematocrit ( J:196405 )
• more pronounced than in Bcl11atm1Phi/Bcl11atm1Phi Eportm1(EGFP/cre)Uk/Epor+ Tg(HBB)8.1Gvs mice
decreased hemoglobin content ( J:196405 )
• more pronounced than in Bcl11atm1Phi/Bcl11atm1Phi Eportm1(EGFP/cre)Uk/Epor+ Tg(HBB)8.1Gvs mice
polychromatophilia ( J:196405 )
• more so than in Bcl11atm1Phi/Bcl11atm1Phi Klf1tm1Nimr/Klf1+ Tg(HBB)8.1Gvs mice

homeostasis/metabolism
increased circulating erythropoietin level ( J:196405 )
• indicating anemic stress




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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory