Phenotypes associated with this allele

• Allele Symbol: Tg(HBB)8.1Gvs
• Allele Name: transgene insertion 8.1, Frank Grosveld
• Allele ID: MGI:5496829
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Bcl11a^tm1Mbu/Bcl11a^tm1Mbu Epor^tm1.1(EGFP/icre)Uk/Epor^+ Tg(HBB)8.1Gvs/0	involves: 129 * BALB/cJ * FVB/N	MGI:5496871
cn2	Bcl11a^tm1Mbu/Bcl11a^tm1Mbu Klf1^tm1Nimr/Klf1^+ Epor^tm1.1(EGFP/icre)Uk/Epor^+ Tg(HBB)8.1Gvs/0	involves: 129P2/OlaHsd * BALB/cJ * FVB/N	MGI:5496872
cn3	Bcl11a^tm1Mbu/Bcl11a^tm1Mbu Klf1^tm1Nimr/Klf1^+ Tg(HBB)8.1Gvs/0	involves: 129P2/OlaHsd * FVB	MGI:5496870

Genotype
MGI:5496871

cn1

• Allelic Composition: Bcl11a^tm1Mbu/Bcl11a^tm1Mbu; Epor^{tm1.1(EGFP/icre)Uk}/Epor⁺; Tg(HBB)8.1Gvs/0
• Genetic Background: involves: 129 * BALB/cJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:196405 )

N • mice are produced in expected Mendelian ratios

hematopoietic system

abnormal erythropoiesis ( J:196405 )

• increased Ter119+/CD71+ cells in the blood

• increased Ter119+/DRAQ5+ cells in the blood

anemia ( J:196405 )

• mild

decreased erythrocyte cell number ( J:196405 )

• small

decreased hematocrit ( J:196405 )

• small

decreased hemoglobin content ( J:196405 )

• small

reticulocytosis ( J:196405 )

homeostasis/metabolism

increased circulating erythropoietin level ( J:196405 )

• indicating anemic stress

Genotype
MGI:5496872

cn2

• Allelic Composition: Bcl11a^tm1Mbu/Bcl11a^tm1Mbu; Klf1^tm1Nimr/Klf1⁺; Epor^{tm1.1(EGFP/icre)Uk}/Epor⁺; Tg(HBB)8.1Gvs/0
• Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * FVB/N

hematopoietic system

abnormal erythropoiesis ( J:196405 )

• increased Ter119+/CD71+ cells in the blood

polychromatophilia ( J:196405 )

Genotype
MGI:5496870

cn3

• Allelic Composition: Bcl11a^tm1Mbu/Bcl11a^tm1Mbu; Klf1^tm1Nimr/Klf1⁺; Tg(HBB)8.1Gvs/0
• Genetic Background: involves: 129P2/OlaHsd * FVB

mortality/aging

mortality/aging ( J:196405 )

N • mice are produced in expected Mendelian ratios

hematopoietic system

abnormal erythropoiesis ( J:196405 )

• increased CD71-/Ter119+ cells in the blood and liver at E18.5

• increased Ter119+/CD71+ cells in the blood

• increased Ter119+/DRAQ5+ cells in the blood

anemia ( J:196405 )

• mild

decreased erythrocyte cell number ( J:196405 )

• more pronounced than in Bcl11a^tm1Phi/Bcl11a^tm1Phi Epor^{tm1(EGFP/cre)Uk}/Epor⁺ Tg(HBB)8.1Gvs mice

decreased hematocrit ( J:196405 )

• more pronounced than in Bcl11a^tm1Phi/Bcl11a^tm1Phi Epor^{tm1(EGFP/cre)Uk}/Epor⁺ Tg(HBB)8.1Gvs mice

decreased hemoglobin content ( J:196405 )

• more pronounced than in Bcl11a^tm1Phi/Bcl11a^tm1Phi Epor^{tm1(EGFP/cre)Uk}/Epor⁺ Tg(HBB)8.1Gvs mice

decreased mean corpuscular hemoglobin ( J:196405 )

• small

decreased mean corpuscular volume ( J:196405 )

• small

polychromatophilia ( J:196405 )

• more so than in Bcl11a^tm1Phi/Bcl11a^tm1Phi Klf1^tm1Nimr/Klf1⁺ Tg(HBB)8.1Gvs mice

reticulocytosis ( J:196405 )

homeostasis/metabolism

increased circulating erythropoietin level ( J:196405 )

• indicating anemic stress